Gene description for Cpne6
Gene name copine VI
Gene symbol Cpne6
Other names/aliases AU067659
BB076446
Species Mus musculus
 Database cross references - Cpne6
ExoCarta ExoCarta_12891
Vesiclepedia VP_12891
Entrez Gene 12891
UniProt Q9Z140  
 Cpne6 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Cpne6
Molecular Function
    phosphatidylserine binding GO:0001786 IDA
    protein binding GO:0005515 IPI
    calcium-dependent phospholipid binding GO:0005544 IBA
    calcium-dependent phospholipid binding GO:0005544 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    cell differentiation GO:0030154 IEA
    cellular response to calcium ion GO:0071277 IBA
    cellular response to calcium ion GO:0071277 IMP
    postsynaptic actin cytoskeleton organization GO:0098974 EXP
    postsynaptic actin cytoskeleton organization GO:0098974 IDA
    postsynaptic actin cytoskeleton organization GO:0098974 IMP
    positive regulation of dendrite extension GO:1903861 IEA
    positive regulation of dendrite extension GO:1903861 ISO
Subcellular Localization
    cytoplasm GO:0005737 IDA
    endosome GO:0005768 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    membrane GO:0016020 IDA
    axon GO:0030424 IDA
    dendrite GO:0030425 IDA
    perikaryon GO:0043204 IEA
    clathrin-coated endocytic vesicle GO:0045334 IDA
 Experiment description of studies that identified Cpne6 in exosomes
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Cpne6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Os9  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
2 Mapt  
Affinity Capture-MS Mus musculus
3 Eed  
Affinity Capture-MS Mus musculus
4 Htt  
Affinity Capture-MS Mus musculus
5 Kctd13  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Cpne6 is involved
PathwayEvidenceSource
Glycerophospholipid biosynthesis IEA Reactome
Metabolism IEA Reactome
Metabolism of lipids IEA Reactome
Phospholipid metabolism IEA Reactome





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