Gene description for Cr1l
Gene name complement component (3b/4b) receptor 1-like
Gene symbol Cr1l
Other names/aliases Crry
Mcp
mCRY
Species Mus musculus
 Database cross references - Cr1l
ExoCarta ExoCarta_12946
Vesiclepedia VP_12946
Entrez Gene 12946
UniProt Q64735  
 Cr1l identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Cr1l
Molecular Function
    complement component C3b binding GO:0001851 ISO
    complement component C4b binding GO:0001855 ISO
    complement component C4b receptor activity GO:0001861 ISO
    complement component C3b receptor activity GO:0004877 ISO
Biological Process
    in utero embryonic development GO:0001701 IGI
    T cell mediated immunity GO:0002456 IBA
    complement activation GO:0006956 IMP
    complement activation, classical pathway GO:0006958 IEA
    female pregnancy GO:0007565 IEA
    regulation of complement activation GO:0030449 IMP
    regulation of complement activation GO:0030449 ISO
    regulation of complement activation GO:0030449 TAS
    innate immune response GO:0045087 IEA
    negative regulation of complement activation GO:0045916 IMP
    negative regulation of complement activation GO:0045916 ISO
    negative regulation of complement activation, classical pathway GO:0045959 IBA
    cellular response to hypoxia GO:0071456 IDA
    regulation of complement-dependent cytotoxicity GO:1903659 ISO
Subcellular Localization
    extracellular space GO:0005615 IBA
    cytoskeleton GO:0005856 ISO
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISO
    external side of plasma membrane GO:0009897 IDA
    cell surface GO:0009986 IDA
    cell surface GO:0009986 ISO
    basolateral plasma membrane GO:0016323 IDA
    receptor complex GO:0043235 ISO
    plasma membrane raft GO:0044853 ISO
 Experiment description of studies that identified Cr1l in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cr1l
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tmem173  
Proximity Label-MS Mus musculus
View the network image/svg+xml
 Pathways in which Cr1l is involved
No pathways found





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