Gene description for Hapln1
Gene name hyaluronan and proteoglycan link protein 1
Gene symbol Hapln1
Other names/aliases BB099155
CLP
Crtl1
Crtl1l
LP
LP-1
Species Mus musculus
 Database cross references - Hapln1
ExoCarta ExoCarta_12950
Vesiclepedia VP_12950
Entrez Gene 12950
UniProt Q9QUP5  
 Hapln1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Hapln1
Molecular Function
    hyaluronic acid binding GO:0005540 IEA
    extracellular matrix structural constituent conferring compression resistance GO:0030021 RCA
Biological Process
    skeletal system development GO:0001501 IBA
    cell adhesion GO:0007155 IEA
    central nervous system development GO:0007417 IBA
Subcellular Localization
    extracellular region GO:0005576 IEA
    extracellular space GO:0005615 IBA
    extracellular matrix GO:0031012 IDA
    synapse GO:0045202 EXP
    synapse GO:0045202 IBA
    synapse GO:0045202 IDA
    collagen-containing extracellular matrix GO:0062023 HDA
    perineuronal net GO:0072534 IBA
 Experiment description of studies that identified Hapln1 in sEVs
1
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Hapln1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Kctd13  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Hapln1 is involved
PathwayEvidenceSource
ECM proteoglycans IEA Reactome
Extracellular matrix organization IEA Reactome





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