Gene description for Csf1
Gene name	colony stimulating factor 1 (macrophage)
Gene symbol	Csf1
Other names/aliases	C87615 Csfm MCSF op
Species	Mus musculus
Database cross references - Csf1
ExoCarta	ExoCarta_12977
Vesiclepedia	VP_12977
Entrez Gene	12977
UniProt	P07141
Csf1 identified in sEVs derived from the following tissue/cell type
Fibroblasts	23260141

Gene ontology annotations for Csf1

Molecular Function     cytokine activity GO:0005125 IBA     cytokine activity GO:0005125 ISO     macrophage colony-stimulating factor receptor binding GO:0005157 IPI     protein binding GO:0005515 IPI     growth factor activity GO:0008083 IEA     growth factor activity GO:0008083 ISO     identical protein binding GO:0042802 IPI     identical protein binding GO:0042802 ISO     protein homodimerization activity GO:0042803 IPI     protein homodimerization activity GO:0042803 ISO Biological Process     ossification GO:0001503 ISO     neutrophil homeostasis GO:0001780 IMP     positive regulation of cell-matrix adhesion GO:0001954 IGI     osteoclast proliferation GO:0002158 IDA     positive regulation of leukocyte migration GO:0002687 IGI     response to ischemia GO:0002931 IEA     response to ischemia GO:0002931 ISO     developmental process involved in reproduction GO:0003006 IMP     inflammatory response GO:0006954 IEA     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IEA     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 ISO     Ras protein signal transduction GO:0007265 IDA     positive regulation of cell population proliferation GO:0008284 ISO     positive regulation of gene expression GO:0010628 IDA     positive regulation of gene expression GO:0010628 ISO     positive regulation of macrophage derived foam cell differentiation GO:0010744 IEA     positive regulation of macrophage derived foam cell differentiation GO:0010744 ISO     positive regulation of macrophage chemotaxis GO:0010759 IEA     positive regulation of macrophage chemotaxis GO:0010759 ISO     monocyte differentiation GO:0030224 IMP     macrophage differentiation GO:0030225 IMP     macrophage differentiation GO:0030225 ISO     regulation of ossification GO:0030278 IMP     osteoclast differentiation GO:0030316 IBA     osteoclast differentiation GO:0030316 IDA     osteoclast differentiation GO:0030316 IGI     osteoclast differentiation GO:0030316 IMP     osteoclast differentiation GO:0030316 ISO     positive regulation of cell migration GO:0030335 ISO     positive regulation of mononuclear cell proliferation GO:0032946 IEA     positive regulation of mononuclear cell proliferation GO:0032946 ISO     monocyte homeostasis GO:0035702 IMP     macrophage colony-stimulating factor signaling pathway GO:0038145 IDA     positive regulation of multicellular organism growth GO:0040018 IMP     positive regulation of odontogenesis of dentin-containing tooth GO:0042488 IMP     innate immune response GO:0045087 IEA     positive regulation of macrophage differentiation GO:0045651 IBA     positive regulation of macrophage differentiation GO:0045651 IMP     positive regulation of macrophage differentiation GO:0045651 ISO     positive regulation of monocyte differentiation GO:0045657 IMP     positive regulation of osteoclast differentiation GO:0045672 IDA     positive regulation of osteoclast differentiation GO:0045672 IGI     positive regulation of osteoclast differentiation GO:0045672 IMP     positive regulation of osteoclast differentiation GO:0045672 ISO     positive regulation of protein kinase activity GO:0045860 IGI     positive regulation of Ras protein signal transduction GO:0046579 IDA     homeostasis of number of cells within a tissue GO:0048873 IMP     positive regulation of protein metabolic process GO:0051247 IEA     positive regulation of protein metabolic process GO:0051247 ISO     branching involved in mammary gland duct morphogenesis GO:0060444 IMP     mammary gland fat development GO:0060611 IMP     mammary duct terminal end bud growth GO:0060763 IMP     microglial cell proliferation GO:0061518 IGI     macrophage homeostasis GO:0061519 IMP     positive regulation of mononuclear cell migration GO:0071677 ISO     myeloid leukocyte migration GO:0097529 IGI     positive regulation of macrophage proliferation GO:0120041 ISO     positive regulation of macrophage colony-stimulating factor signaling pathway GO:1902228 IEA     positive regulation of macrophage colony-stimulating factor signaling pathway GO:1902228 ISO     positive regulation of microglial cell migration GO:1904141 IEA     positive regulation of microglial cell migration GO:1904141 ISO     positive regulation of macrophage migration GO:1905523 ISO Subcellular Localization     extracellular region GO:0005576 ISO     extracellular region GO:0005576 TAS     extracellular space GO:0005615 HDA     extracellular space GO:0005615 IBA     extracellular space GO:0005615 ISO     plasma membrane GO:0005886 IEA     plasma membrane GO:0005886 ISO     nuclear body GO:0016604 IEA     nuclear body GO:0016604 ISO     perinuclear region of cytoplasm GO:0048471 IEA     perinuclear region of cytoplasm GO:0048471 ISO     CSF1-CSF1R complex GO:1990682 IDA