Gene description for Csf1
Gene name colony stimulating factor 1 (macrophage)
Gene symbol Csf1
Other names/aliases C87615
Species Mus musculus
 Database cross references - Csf1
ExoCarta ExoCarta_12977
Entrez Gene 12977
UniProt P07141  
 Csf1 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Csf1
Molecular Function
    protein binding GO:0005515 IPI
    growth factor activity GO:0008083 ISO
    cytokine activity GO:0005125 ISO
    macrophage colony-stimulating factor receptor binding GO:0005157 IPI
    protein homodimerization activity GO:0042803 ISO
Biological Process
    positive regulation of cell-matrix adhesion GO:0001954 IGI
    positive regulation of monocyte differentiation GO:0045657 IMP
    innate immune response GO:0045087 IEA
    mammary gland fat development GO:0060611 IMP
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 ISO
    cell proliferation GO:0008283 ISO
    positive regulation of osteoclast differentiation GO:0045672 ISO
    positive regulation of mononuclear cell proliferation GO:0032946 ISO
    regulation of ossification GO:0030278 IMP
    positive regulation of cell proliferation GO:0008284 ISO
    positive regulation of protein kinase activity GO:0045860 IGI
    odontogenesis GO:0042476 ISO
    positive regulation of macrophage differentiation GO:0045651 ISO
    positive regulation of gene expression GO:0010628 ISO
    mammary duct terminal end bud growth GO:0060763 IMP
    ossification GO:0001503 ISO
    osteoclast proliferation GO:0002158 IDA
    immune system process GO:0002376 IEA
    positive regulation of microglial cell migration GO:1904141 ISO
    positive regulation of multicellular organism growth GO:0040018 IMP
    developmental process involved in reproduction GO:0003006 IMP
    osteoclast differentiation GO:0030316 ISO
    inflammatory response GO:0006954 IEA
    macrophage colony-stimulating factor signaling pathway GO:0038145 IDA
    positive regulation of macrophage derived foam cell differentiation GO:0010744 ISO
    positive regulation of cellular protein metabolic process GO:0032270 ISO
    positive regulation of macrophage colony-stimulating factor signaling pathway GO:1902228 ISO
    macrophage differentiation GO:0030225 ISO
    positive regulation of cell migration GO:0030335 IGI
    positive regulation of macrophage chemotaxis GO:0010759 ISO
    positive regulation of Ras protein signal transduction GO:0046579 IDA
    branching involved in mammary gland duct morphogenesis GO:0060444 IMP
    positive regulation of odontogenesis of dentin-containing tooth GO:0042488 IMP
    homeostasis of number of cells within a tissue GO:0048873 IMP
Subcellular Localization
    perinuclear region of cytoplasm GO:0048471 ISO
    extracellular exosome GO:0070062 ISO
    membrane GO:0016020 IEA
    extracellular space GO:0005615 ISO
    CSF1-CSF1R complex GO:1990682 IDA
    extracellular region GO:0005576 IEA
    plasma membrane GO:0005886 IEA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified Csf1 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Csf1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Csf1 is involved
No pathways found

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