Gene description for Cxadr
Gene name coxsackie virus and adenovirus receptor
Gene symbol Cxadr
Other names/aliases 2610206D03Rik
AU016810
AW553441
CAR
MCAR
MCVADR
Species Mus musculus
 Database cross references - Cxadr
ExoCarta ExoCarta_13052
Vesiclepedia VP_13052
Entrez Gene 13052
UniProt P97792  
 Cxadr identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Cxadr
Molecular Function
    signaling receptor binding GO:0005102 ISO
    integrin binding GO:0005178 ISO
    protein binding GO:0005515 IPI
    beta-catenin binding GO:0008013 IPI
    beta-catenin binding GO:0008013 ISO
    PDZ domain binding GO:0030165 ISO
    PDZ domain binding GO:0030165 ISS
    identical protein binding GO:0042802 ISO
    cell adhesion molecule binding GO:0050839 IBA
    cell adhesion molecule binding GO:0050839 ISO
    cell adhesion molecule binding GO:0050839 ISS
    connexin binding GO:0071253 IPI
    cell adhesive protein binding involved in AV node cell-bundle of His cell communication GO:0086082 IC
Biological Process
    mitochondrion organization GO:0007005 IMP
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 ISO
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 ISS
    heart development GO:0007507 IMP
    germ cell migration GO:0008354 IEP
    epithelial structure maintenance GO:0010669 ISO
    epithelial structure maintenance GO:0010669 ISS
    actin cytoskeleton organization GO:0030036 ISO
    actin cytoskeleton organization GO:0030036 ISS
    neutrophil chemotaxis GO:0030593 ISO
    neutrophil chemotaxis GO:0030593 ISS
    homotypic cell-cell adhesion GO:0034109 IBA
    homotypic cell-cell adhesion GO:0034109 ISO
    homotypic cell-cell adhesion GO:0034109 ISS
    cell-cell junction organization GO:0045216 IMP
    gamma-delta T cell activation GO:0046629 IDA
    defense response to virus GO:0051607 ISO
    cardiac muscle cell development GO:0055013 IMP
    cardiac muscle cell proliferation GO:0060038 IMP
    negative regulation of cardiac muscle cell proliferation GO:0060044 IMP
    positive regulation of epithelial cell proliferation involved in wound healing GO:0060054 IC
    transepithelial transport GO:0070633 ISO
    AV node cell to bundle of His cell communication GO:0086067 IMP
    AV node cell-bundle of His cell adhesion involved in cell communication GO:0086072 IMP
    cell-cell adhesion GO:0098609 IMP
    regulation of AV node cell action potential GO:0098904 IMP
    regulation of synaptic vesicle endocytosis GO:1900242 IDA
    regulation of synaptic vesicle endocytosis GO:1900242 IMP
Subcellular Localization
    acrosomal vesicle GO:0001669 IDA
    extracellular region GO:0005576 IEA
    extracellular space GO:0005615 ISO
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    cell-cell junction GO:0005911 IDA
    cell-cell junction GO:0005911 ISO
    adherens junction GO:0005912 ISO
    adherens junction GO:0005912 ISS
    bicellular tight junction GO:0005923 IBA
    bicellular tight junction GO:0005923 IDA
    bicellular tight junction GO:0005923 ISO
    intercalated disc GO:0014704 IBA
    intercalated disc GO:0014704 IDA
    intercalated disc GO:0014704 ISO
    basolateral plasma membrane GO:0016323 IBA
    basolateral plasma membrane GO:0016323 IDA
    basolateral plasma membrane GO:0016323 IEA
    basolateral plasma membrane GO:0016323 ISO
    apicolateral plasma membrane GO:0016327 ISO
    apicolateral plasma membrane GO:0016327 ISS
    cell junction GO:0030054 ISO
    filopodium GO:0030175 IDA
    growth cone GO:0030426 IDA
    neuromuscular junction GO:0031594 ISO
    protein-containing complex GO:0032991 ISO
    presynaptic membrane GO:0042734 IDA
    presynaptic membrane GO:0042734 IEP
    neuron projection GO:0043005 IDA
    neuron projection GO:0043005 ISO
    cell body GO:0044297 IDA
    membrane raft GO:0045121 ISO
    membrane raft GO:0045121 ISS
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IEP
    glutamatergic synapse GO:0098978 IMP
    GABA-ergic synapse GO:0098982 IDA
    GABA-ergic synapse GO:0098982 IEP
 Experiment description of studies that identified Cxadr in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Cxadr
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ncoa1  
Co-fractionation Mus musculus
2 Sstr3  
Proximity Label-MS Mus musculus
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