Gene description for ADAD1
Gene name adenosine deaminase domain containing 1 (testis-specific)
Gene symbol ADAD1
Other names/aliases Tenr
Species Homo sapiens
 Database cross references - ADAD1
ExoCarta ExoCarta_132612
Vesiclepedia VP_132612
Entrez Gene 132612
HGNC 30713
MIM 614130
UniProt Q96M93  
 ADAD1 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for ADAD1
Molecular Function
    double-stranded RNA binding GO:0003725 IBA
    double-stranded RNA adenosine deaminase activity GO:0003726 IBA
    adenosine deaminase activity GO:0004000 IEA
    tRNA-specific adenosine deaminase activity GO:0008251 IBA
Biological Process
    adenosine to inosine editing GO:0006382 IBA
    RNA processing GO:0006396 IBA
    spermatid development GO:0007286 IEA
Subcellular Localization
    male germ cell nucleus GO:0001673 IEA
    nucleolus GO:0005730 IBA
    cytoplasm GO:0005737 IBA
 Experiment description of studies that identified ADAD1 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ADAD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ADAD1 is involved
No pathways found





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