Gene description for ADM
Gene name	adrenomedullin
Gene symbol	ADM
Other names/aliases	AM PAMP
Species	Homo sapiens
Database cross references - ADM
ExoCarta	ExoCarta_133
Vesiclepedia	VP_133
Entrez Gene	133
HGNC	259
MIM	103275
UniProt	P35318
ADM identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Pancreatic cancer cells	26061593
Pancreatic cancer cells	26061593
Pancreatic cancer cells	26061593
Pancreatic cancer cells	26061593
Plasma	26061593
Plasma	26061593

Gene ontology annotations for ADM

Molecular Function     signaling receptor binding GO:0005102 TAS     hormone activity GO:0005179 IDA     adrenomedullin receptor binding GO:0031700 IBA     adrenomedullin receptor binding GO:0031700 IDA Biological Process     vasculogenesis GO:0001570 IDA     response to hypoxia GO:0001666 IEA     neural tube closure GO:0001843 IEA     response to yeast GO:0001878 IDA     regulation of the force of heart contraction GO:0002026 IEA     G protein-coupled receptor internalization GO:0002031 IDA     regulation of systemic arterial blood pressure GO:0003073 IBA     regulation of systemic arterial blood pressure GO:0003073 IDA     inflammatory response GO:0006954 TAS     signal transduction GO:0007165 TAS     adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 IBA     adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 IDA     positive regulation of cytosolic calcium ion concentration GO:0007204 IEA     heart development GO:0007507 IEA     female pregnancy GO:0007565 IEA     androgen metabolic process GO:0008209 IEA     cell population proliferation GO:0008283 IEA     positive regulation of cell population proliferation GO:0008284 IEA     negative regulation of cell population proliferation GO:0008285 IEA     positive regulation of heart rate GO:0010460 IBA     positive regulation of heart rate GO:0010460 IDA     antibacterial humoral response GO:0019731 IDA     antifungal humoral response GO:0019732 IDA     cAMP-mediated signaling GO:0019933 IEA     animal organ regeneration GO:0031100 IEA     neuron projection regeneration GO:0031102 IEA     receptor internalization GO:0031623 IDA     response to lipopolysaccharide GO:0032496 IEA     response to insulin GO:0032868 IEA     regulation of urine volume GO:0035809 IDA     odontogenesis of dentin-containing tooth GO:0042475 IEA     response to starvation GO:0042594 IEA     positive regulation of apoptotic process GO:0043065 IEA     negative regulation of vascular permeability GO:0043116 IEA     response to ether GO:0045472 IEA     positive regulation of angiogenesis GO:0045766 IEA     negative regulation of vasoconstriction GO:0045906 IDA     developmental growth GO:0048589 IEA     defense response to Gram-negative bacterium GO:0050829 IDA     defense response to Gram-positive bacterium GO:0050830 IDA     response to glucocorticoid GO:0051384 IEA     branching involved in labyrinthine layer morphogenesis GO:0060670 IEA     antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IDA     vascular associated smooth muscle cell development GO:0097084 IEA     adrenomedullin receptor signaling pathway GO:1990410 IBA     adrenomedullin receptor signaling pathway GO:1990410 IDA     positive regulation of progesterone biosynthetic process GO:2000184 TAS     positive regulation of vasculogenesis GO:2001214 IEA Subcellular Localization     extracellular region GO:0005576 TAS     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IDA     cytoplasm GO:0005737 IDA