Gene description for Dhcr7
Gene name 7-dehydrocholesterol reductase
Gene symbol Dhcr7
Other names/aliases AA409147
Species Mus musculus
 Database cross references - Dhcr7
ExoCarta ExoCarta_13360
Entrez Gene 13360
UniProt O88455  
 Dhcr7 identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Dhcr7
Molecular Function
    oxidoreductase activity GO:0016491 IEA
    oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor GO:0016628 IEA
    7-dehydrocholesterol reductase activity GO:0047598 ISO
Biological Process
    cholesterol metabolic process GO:0008203 IEA
    post-embryonic development GO:0009791 IMP
    regulation of cell proliferation GO:0042127 IMP
    lung development GO:0030324 IMP
    lipid metabolic process GO:0006629 IEA
    steroid biosynthetic process GO:0006694 IEA
    blood vessel development GO:0001568 IMP
    sterol biosynthetic process GO:0016126 IMP
    steroid metabolic process GO:0008202 IEA
    cell differentiation GO:0030154 IMP
    multicellular organism growth GO:0035264 IMP
    cholesterol biosynthetic process GO:0006695 ISO
    oxidation-reduction process GO:0055114 IDA
    regulation of cholesterol biosynthetic process GO:0045540 ISO
Subcellular Localization
    nuclear outer membrane GO:0005640 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    membrane GO:0016020 ISO
    endoplasmic reticulum GO:0005783 ISO
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified Dhcr7 in exosomes
1
Experiment ID 264
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th2 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Dhcr7
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Dhcr7 is involved
PathwayEvidenceSource
Activation of gene expression by SREBF (SREBP) IEA Reactome
Cholesterol biosynthesis IEA Reactome





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