Gene description for Dll1
Gene name delta-like 1 (Drosophila)
Gene symbol Dll1
Other names/aliases Delta1
Species Mus musculus
 Database cross references - Dll1
ExoCarta ExoCarta_13388
Entrez Gene 13388
UniProt Q61483  
 Dll1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Dll1
Molecular Function
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    Notch binding GO:0005112 ISO
Biological Process
    regulation of neurogenesis GO:0050767 IMP
    heart looping GO:0001947 IMP
    negative regulation of myeloid cell differentiation GO:0045638 IDA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP
    positive regulation of Notch signaling pathway GO:0045747 IDA
    odontogenesis of dentin-containing tooth GO:0042475 NAS
    compartment pattern specification GO:0007386 IMP
    nervous system development GO:0007399 NAS
    left/right axis specification GO:0070986 IMP
    cell communication GO:0007154 IEA
    inner ear development GO:0048839 IMP
    somite specification GO:0001757 IMP
    negative regulation of cell differentiation GO:0045596 IMP
    determination of left/right symmetry GO:0007368 IMP
    inner ear morphogenesis GO:0042472 NAS
    cell-cell signaling GO:0007267 IDA
    auditory receptor cell differentiation GO:0042491 NAS
    negative regulation of interleukin-10 production GO:0032693 ISO
    cell differentiation GO:0030154 IEA
    in utero embryonic development GO:0001701 NAS
    multicellular organismal development GO:0007275 IEA
    auditory receptor cell fate commitment GO:0009912 NAS
    Notch signaling pathway GO:0007219 TAS
    Notch signaling involved in heart development GO:0061314 IC
    somitogenesis GO:0001756 IGI
    negative regulation of auditory receptor cell differentiation GO:0045608 IMP
    negative regulation of neuron differentiation GO:0045665 IMP
    organ morphogenesis GO:0009887 NAS
Subcellular Localization
    membrane GO:0016020 IEA
    integral component of membrane GO:0016021 IEA
    cytoplasmic vesicle GO:0031410 IDA
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified Dll1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Dll1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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