Gene description for Dlx2
Gene name distal-less homeobox 2
Gene symbol Dlx2
Other names/aliases AW121999
Dlx-2
Tes-1
Species Mus musculus
 Database cross references - Dlx2
ExoCarta ExoCarta_13392
Entrez Gene 13392
UniProt P40764  
 Dlx2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Dlx2
Molecular Function
    sequence-specific DNA binding GO:0043565 IEA
    chromatin binding GO:0003682 IDA
    DNA binding GO:0003677 IDA
    protein binding GO:0005515 IPI
    RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 IDA
    RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001228 IDA
    single-stranded RNA binding GO:0003727 IPI
Biological Process
    branching morphogenesis of a nerve GO:0048755 IMP
    embryonic cranial skeleton morphogenesis GO:0048701 IMP
    cell differentiation GO:0030154 IMP
    regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment GO:0021882 IGI
    transcription from RNA polymerase II promoter GO:0006366 IDA
    regulation of transcription, DNA-templated GO:0006355 IEA
    cerebral cortex GABAergic interneuron differentiation GO:0021892 IGI
    hippocampus development GO:0021766 IGI
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IGI
    subpallium development GO:0021544 IGI
    negative regulation of oligodendrocyte differentiation GO:0048715 IGI
    cerebral cortex GABAergic interneuron fate commitment GO:0021893 IGI
    olfactory bulb development GO:0021772 IMP
    odontogenesis of dentin-containing tooth GO:0042475 IGI
    multicellular organismal development GO:0007275 IEA
    forebrain neuron differentiation GO:0021879 IGI
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IGI
    cartilage development GO:0051216 IMP
    regulation of transcription from RNA polymerase II promoter GO:0006357 IGI
    negative regulation of Notch signaling pathway GO:0045746 IGI
    proximal/distal pattern formation GO:0009954 IMP
    embryonic skeletal system development GO:0048706 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
 Experiment description of studies that identified Dlx2 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Dlx2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Dlx2 is involved
No pathways found





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