Gene description for Dlx2
Gene name distal-less homeobox 2
Gene symbol Dlx2
Other names/aliases AW121999
Dlx-2
Tes-1
Species Mus musculus
 Database cross references - Dlx2
ExoCarta ExoCarta_13392
Vesiclepedia VP_13392
Entrez Gene 13392
UniProt P40764  
 Dlx2 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Dlx2
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IDA
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA
    DNA binding GO:0003677 IDA
    chromatin binding GO:0003682 IDA
    single-stranded RNA binding GO:0003727 IPI
    protein binding GO:0005515 IPI
    sequence-specific double-stranded DNA binding GO:1990837 ISO
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IGI
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    regulation of transcription by RNA polymerase II GO:0006357 IGI
    Notch signaling pathway GO:0007219 IGI
    proximal/distal pattern formation GO:0009954 IGI
    proximal/distal pattern formation GO:0009954 IMP
    neuroblast differentiation GO:0014016 IMP
    subpallium development GO:0021544 IGI
    hippocampus development GO:0021766 IGI
    olfactory bulb development GO:0021772 IMP
    forebrain neuron differentiation GO:0021879 IGI
    cerebral cortex GABAergic interneuron differentiation GO:0021892 IGI
    cerebral cortex GABAergic interneuron fate commitment GO:0021893 IGI
    cell differentiation GO:0030154 IBA
    odontogenesis of dentin-containing tooth GO:0042475 IGI
    positive regulation of cell differentiation GO:0045597 IMP
    negative regulation of Notch signaling pathway GO:0045746 IGI
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IGI
    negative regulation of photoreceptor cell differentiation GO:0046533 IMP
    embryonic cranial skeleton morphogenesis GO:0048701 IMP
    embryonic skeletal system development GO:0048706 IBA
    embryonic skeletal system development GO:0048706 IGI
    embryonic skeletal system development GO:0048706 IMP
    oligodendrocyte differentiation GO:0048709 IGI
    negative regulation of oligodendrocyte differentiation GO:0048715 IGI
    branching morphogenesis of a nerve GO:0048755 IMP
    cartilage development GO:0051216 IMP
    GABAergic neuron differentiation GO:0097154 IGI
    positive regulation of amacrine cell differentiation GO:1902871 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
 Experiment description of studies that identified Dlx2 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Dlx2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Sp7  
Two-hybrid Mus musculus
2 Dlx1  
Two-hybrid Mus musculus
3 Msx1  
Two-hybrid Mus musculus
4 Alx4  
Two-hybrid Mus musculus
View the network image/svg+xml
 Pathways in which Dlx2 is involved
No pathways found





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