Gene description for Dpp4
Gene name dipeptidylpeptidase 4
Gene symbol Dpp4
Other names/aliases Cd26
Dpp-4
THAM
Species Mus musculus
 Database cross references - Dpp4
ExoCarta ExoCarta_13482
Vesiclepedia VP_13482
Entrez Gene 13482
UniProt P28843  
 Dpp4 identified in sEVs derived from the following tissue/cell type
Faeces 33431899    
Faeces 33431899    
 Gene ontology annotations for Dpp4
Molecular Function
    virus receptor activity GO:0001618 IEA
    virus receptor activity GO:0001618 ISO
    protease binding GO:0002020 ISO
    protease binding GO:0002020 ISS
    aminopeptidase activity GO:0004177 IEA
    serine-type endopeptidase activity GO:0004252 IEA
    serine-type endopeptidase activity GO:0004252 ISO
    signaling receptor binding GO:0005102 ISO
    signaling receptor binding GO:0005102 ISS
    collagen binding GO:0005518 ISO
    serine-type peptidase activity GO:0008236 ISO
    dipeptidyl-peptidase activity GO:0008239 IBA
    dipeptidyl-peptidase activity GO:0008239 ISO
    dipeptidyl-peptidase activity GO:0008239 ISS
    peptide binding GO:0042277 ISO
    identical protein binding GO:0042802 ISO
    protein homodimerization activity GO:0042803 ISO
    protein homodimerization activity GO:0042803 ISS
    chemorepellent activity GO:0045499 IEA
    chemorepellent activity GO:0045499 ISO
Biological Process
    behavioral fear response GO:0001662 IMP
    response to hypoxia GO:0001666 IEA
    response to hypoxia GO:0001666 ISO
    B-1a B cell differentiation GO:0002337 ISO
    regulation of T cell mediated immunity GO:0002709 ISO
    positive regulation of natural killer cell mediated immunity GO:0002717 ISO
    proteolysis GO:0006508 IBA
    proteolysis GO:0006508 IEA
    proteolysis GO:0006508 ISO
    cell adhesion GO:0007155 IEA
    positive regulation of cell population proliferation GO:0008284 ISO
    positive regulation of cell population proliferation GO:0008284 ISS
    negative regulation of extracellular matrix disassembly GO:0010716 ISO
    negative regulation of extracellular matrix disassembly GO:0010716 ISS
    protein catabolic process GO:0030163 ISO
    T cell costimulation GO:0031295 ISO
    T cell costimulation GO:0031295 ISS
    regulation of cell-cell adhesion mediated by integrin GO:0033632 IEA
    regulation of cell-cell adhesion mediated by integrin GO:0033632 ISO
    locomotory exploration behavior GO:0035641 IMP
    psychomotor behavior GO:0036343 IMP
    T cell activation GO:0042110 IEA
    T cell activation GO:0042110 ISO
    endothelial cell migration GO:0043542 ISO
    endothelial cell migration GO:0043542 ISS
    symbiont entry into host cell GO:0046718 IEA
    negative chemotaxis GO:0050919 IEA
    negative regulation of neutrophil chemotaxis GO:0090024 IEA
    negative regulation of neutrophil chemotaxis GO:0090024 ISO
Subcellular Localization
    extracellular region GO:0005576 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISO
    cell surface GO:0009986 ISO
    cell surface GO:0009986 ISS
    apical plasma membrane GO:0016324 IEA
    apical plasma membrane GO:0016324 ISO
    lamellipodium GO:0030027 ISO
    lamellipodium GO:0030027 ISS
    endocytic vesicle GO:0030139 ISO
    endocytic vesicle GO:0030139 ISS
    lamellipodium membrane GO:0031258 IEA
    membrane raft GO:0045121 IEA
    intercellular canaliculus GO:0046581 IDA
 Experiment description of studies that identified Dpp4 in sEVs
1
Experiment ID 303
MISEV standards
EM
Biophysical techniques
Cd63|Cd81|Cd9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33431899    
Organism Mus musculus
Experiment description High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
Authors "Kumar A, Sundaram K, Mu J, Dryden GW, Sriwastva MK, Lei C, Zhang L, Qiu X, Xu F, Yan J, Zhang X, Park JW, Merchant ML, Bohler HCL, Wang B, Zhang S, Qin C, Xu Z, Han X, McClain CJ, Teng Y, Zhang HG."
Journal name Nat Commun
Publication year 2021
Sample Faeces
Sample name Intestinal epithelial cells - C57BL/6
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Lipid
miRNA
Methods used in the study Western blotting
Mass spectrometry
Immunofluorescence
miRNA array
HPLC
2
Experiment ID 304
MISEV standards
EM
Biophysical techniques
Cd63|Cd81|Cd9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33431899    
Organism Mus musculus
Experiment description High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
Authors "Kumar A, Sundaram K, Mu J, Dryden GW, Sriwastva MK, Lei C, Zhang L, Qiu X, Xu F, Yan J, Zhang X, Park JW, Merchant ML, Bohler HCL, Wang B, Zhang S, Qin C, Xu Z, Han X, McClain CJ, Teng Y, Zhang HG."
Journal name Nat Commun
Publication year 2021
Sample Faeces
Sample name Intestinal epithelial cells - C57BL/6
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Lipid
miRNA
Methods used in the study Western blotting
Mass spectrometry
Immunofluorescence
miRNA array
HPLC
 Protein-protein interactions for Dpp4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Invs  
Affinity Capture-MS Mus musculus
2 Pgrmc1  
Co-fractionation Mus musculus
3 Vip  
Co-fractionation Mus musculus
4 Nt5dc3  
Co-fractionation Mus musculus
5 Ccl11  
Co-fractionation Mus musculus
6 Npy  
Co-fractionation Mus musculus
7 Dpp10  
Co-fractionation Mus musculus
8 Dpp6  
Co-fractionation Mus musculus
9 Ghrh  
Co-fractionation Mus musculus
View the network image/svg+xml



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