Gene description for CPB1
Gene name carboxypeptidase B1 (tissue)
Gene symbol CPB1
Other names/aliases CPB
PASP
PCPB
Species Homo sapiens
 Database cross references - CPB1
ExoCarta ExoCarta_1360
Entrez Gene 1360
HGNC 2299
MIM 114852
UniProt P15086  
 CPB1 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for CPB1
Molecular Function
    metallocarboxypeptidase activity GO:0004181 IEA
    carboxypeptidase activity GO:0004180 TAS
    zinc ion binding GO:0008270 IEA
Biological Process
    proteolysis GO:0006508 IEA
Subcellular Localization
    extracellular region GO:0005576 IEA
 Experiment description of studies that identified CPB1 in exosomes
1
Experiment ID 275
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|RAB5A
EV Cytosolic markers
✔
CD9|CD82|CD63|CD81
EV Membrane markers
✔
AIF
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for CPB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CPB1 is involved
PathwayEvidenceSource
Metabolism of Angiotensinogen to Angiotensins TAS Reactome





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