Gene description for CPB1
Gene name carboxypeptidase B1 (tissue)
Gene symbol CPB1
Other names/aliases CPB
PASP
PCPB
Species Homo sapiens
 Database cross references - CPB1
ExoCarta ExoCarta_1360
Vesiclepedia VP_1360
Entrez Gene 1360
HGNC 2299
MIM 114852
UniProt P15086  
 CPB1 identified in sEVs derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for CPB1
Molecular Function
    carboxypeptidase activity GO:0004180 IDA
    metallocarboxypeptidase activity GO:0004181 IBA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
Biological Process
    proteolysis GO:0006508 IBA
    proteolysis GO:0006508 IDA
Subcellular Localization
    extracellular space GO:0005615 IBA
    cytoplasmic vesicle GO:0031410 IEA
 Experiment description of studies that identified CPB1 in sEVs
1
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for CPB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CPB1 is involved
PathwayEvidenceSource
Metabolism of Angiotensinogen to Angiotensins TAS Reactome
Metabolism of proteins TAS Reactome
Peptide hormone metabolism TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here