Gene description for Egr2
Gene name	early growth response 2
Gene symbol	Egr2
Other names/aliases	Egr-2 Krox-20 Krox20 NGF1-B Zfp-25 Zfp-6
Species	Mus musculus
Database cross references - Egr2
ExoCarta	ExoCarta_13654
Vesiclepedia	VP_13654
Entrez Gene	13654
UniProt	P08152
Egr2 identified in sEVs derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Egr2

Molecular Function     transcription cis-regulatory region binding GO:0000976 IDA     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 ISO     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IDA     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISO     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISS     DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IEA     DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 ISO     DNA binding GO:0003677 IDA     chromatin binding GO:0003682 IDA     DNA-binding transcription factor activity GO:0003700 IDA     DNA-binding transcription factor activity GO:0003700 IMP     DNA-binding transcription factor activity GO:0003700 ISO     protein binding GO:0005515 IPI     ubiquitin protein ligase binding GO:0031625 IEA     ubiquitin protein ligase binding GO:0031625 ISO     sequence-specific DNA binding GO:0043565 IDA     sequence-specific DNA binding GO:0043565 ISO     sequence-specific DNA binding GO:0043565 ISS     metal ion binding GO:0046872 IEA     RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI     SUMO ligase activity GO:0061665 IDA     HMG box domain binding GO:0071837 IEA     HMG box domain binding GO:0071837 ISO     sequence-specific double-stranded DNA binding GO:1990837 ISO Biological Process     regulation of DNA-templated transcription GO:0006355 IMP     regulation of transcription by RNA polymerase II GO:0006357 IBA     protein export from nucleus GO:0006611 IDA     learning or memory GO:0007611 IEA     rhythmic behavior GO:0007622 IDA     rhythmic behavior GO:0007622 IMP     motor neuron axon guidance GO:0008045 IGI     gene expression GO:0010467 IMP     gene expression GO:0010467 IMP     Schwann cell differentiation GO:0014037 IMP     Schwann cell differentiation GO:0014037 IMP     positive regulation of Schwann cell differentiation GO:0014040 IMP     protein sumoylation GO:0016925 IDA     protein sumoylation GO:0016925 IEA     rhombomere 3 development GO:0021569 IGI     facial nerve structural organization GO:0021612 IGI     facial nerve structural organization GO:0021612 IMP     rhombomere 3 structural organization GO:0021659 IDA     rhombomere 3 formation GO:0021660 IMP     rhombomere 5 structural organization GO:0021665 IDA     rhombomere 5 structural organization GO:0021665 IMP     rhombomere 5 formation GO:0021666 IMP     regulation of ossification GO:0030278 IMP     positive regulation of myelination GO:0031643 IMP     response to insulin GO:0032868 IEA     response to insulin GO:0032868 ISO     brain segmentation GO:0035284 IMP     aorta development GO:0035904 IMP     skeletal muscle cell differentiation GO:0035914 IMP     skeletal muscle cell differentiation GO:0035914 IMP     myelination GO:0042552 IMP     fat cell differentiation GO:0045444 IMP     positive regulation of DNA-templated transcription GO:0045893 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 ISO     positive regulation of transcription by RNA polymerase II GO:0045944 ISS     regulation of neuronal synaptic plasticity GO:0048168 IEA Subcellular Localization     nucleus GO:0005634 IC     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 ISO     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 IDA     intracellular membrane-bounded organelle GO:0043231 ISO