Gene description for Egr2
Gene name early growth response 2
Gene symbol Egr2
Other names/aliases Egr-2
Species Mus musculus
 Database cross references - Egr2
ExoCarta ExoCarta_13654
Entrez Gene 13654
UniProt P08152  
 Egr2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Egr2
Molecular Function
    protein-glycine ligase activity GO:0070735 IEA
    coenzyme F420-0 gamma-glutamyl ligase activity GO:0043773 IEA
    metal ion binding GO:0046872 IEA
    DNA binding GO:0003677 IDA
    protein-glycine ligase activity, elongating GO:0070737 IEA
    sequence-specific DNA binding transcription factor activity GO:0003700 ISO
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 ISO
    protein-glycine ligase activity, initiating GO:0070736 IEA
    transcription regulatory region DNA binding GO:0044212 IDA
    ligase activity GO:0016874 IEA
    ubiquitin protein ligase binding GO:0031625 ISO
    tubulin-glutamic acid ligase activity GO:0070740 IEA
    ribosomal S6-glutamic acid ligase activity GO:0018169 IEA
    tubulin-glycine ligase activity GO:0070738 IEA
    protein binding GO:0005515 IPI
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 ISO
    protein-glutamic acid ligase activity GO:0070739 IEA
    UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity GO:0008766 IEA
    chromatin binding GO:0003682 IDA
    coenzyme F420-2 alpha-glutamyl ligase activity GO:0043774 IEA
    HMG box domain binding GO:0071837 ISO
    nucleic acid binding GO:0003676 IEA
    RNA polymerase II activating transcription factor binding GO:0001102 IPI
Biological Process
    rhythmic behavior GO:0007622 IMP
    regulation of transcription, DNA-templated GO:0006355 IMP
    rhombomere 5 formation GO:0021666 IMP
    negative regulation of apoptotic process GO:0043066 IBA
    regulation of ossification GO:0030278 IMP
    regulation of neuronal synaptic plasticity GO:0048168 IBA
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    motor neuron axon guidance GO:0008045 IGI
    Schwann cell differentiation GO:0014037 IMP
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    fat cell differentiation GO:0045444 IMP
    rhombomere 3 formation GO:0021660 IMP
    rhombomere 3 development GO:0021569 IGI
    cellular response to cAMP GO:0071320 IBA
    response to insulin GO:0032868 ISO
    facial nerve structural organization GO:0021612 IGI
    brain segmentation GO:0035284 IMP
    transcription, DNA-templated GO:0006351 IEA
    transcription from RNA polymerase II promoter GO:0006366 ISO
    protein export from nucleus GO:0006611 IDA
    cellular response to gonadotropin stimulus GO:0071371 IBA
    myelination GO:0042552 IMP
    cellular response to organic substance GO:0071310 IDA
    skeletal muscle cell differentiation GO:0035914 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified Egr2 in exosomes
Experiment ID 15
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
 Protein-protein interactions for Egr2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.

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