Gene description for UNC5D
Gene name unc-5 homolog D (C. elegans)
Gene symbol UNC5D
Other names/aliases PRO34692
Unc5h4
Species Homo sapiens
 Database cross references - UNC5D
ExoCarta ExoCarta_137970
Entrez Gene 137970
HGNC 18634
UniProt Q6UXZ4  
 UNC5D identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for UNC5D
Biological Process
    regulation of neuron migration GO:2001222 IEA
    signal transduction GO:0007165 IEA
    apoptotic process GO:0006915 IEA
    axon guidance GO:0007411 TAS
    pyramidal neuron differentiation GO:0021859 IEA
Subcellular Localization
    cell surface GO:0009986 IEA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified UNC5D in exosomes
1
Experiment ID 224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for UNC5D
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which UNC5D is involved
PathwayEvidenceSource
Netrin mediated repulsion signals TAS Reactome





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