Gene description for Enpep
Gene name glutamyl aminopeptidase
Gene symbol Enpep
Other names/aliases 6030431M22Rik
Species Mus musculus
 Database cross references - Enpep
ExoCarta ExoCarta_13809
Entrez Gene 13809
UniProt P16406  
 Enpep identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Enpep
Molecular Function
    peptidase activity GO:0008233 IDA
    zinc ion binding GO:0008270 IEA
    metallopeptidase activity GO:0008237 ISO
    hydrolase activity GO:0016787 IEA
    aminopeptidase activity GO:0004177 ISO
    metal ion binding GO:0046872 IEA
    metalloaminopeptidase activity GO:0070006 ISO
    peptide binding GO:0042277 ISO
Biological Process
    cell migration GO:0016477 ISO
    cellular aromatic compound metabolic process GO:0006725 ISO
    angiogenesis GO:0001525 IMP
    proteolysis GO:0006508 ISO
    regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 ISO
    cell proliferation GO:0008283 ISO
Subcellular Localization
    vesicle membrane GO:0012506 ISO
    cytoplasmic vesicle GO:0031410 IDA
    plasma membrane GO:0005886 TAS
    brush border GO:0005903 IDA
    extracellular exosome GO:0070062 ISO
    external side of plasma membrane GO:0009897 IDA
    lysosomal membrane GO:0005765 ISO
    apical plasma membrane GO:0016324 IDA
    apical part of cell GO:0045177 IDA
    vesicle lumen GO:0031983 ISO
    integral component of membrane GO:0016021 IEA
    membrane GO:0016020 IEA
 Experiment description of studies that identified Enpep in exosomes
Experiment ID 188
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Enpep
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Enpep is involved
Metabolism of Angiotensinogen to Angiotensins IEA Reactome

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