Gene description for Epha5
Gene name Eph receptor A5
Gene symbol Epha5
Other names/aliases AI854630
Species Mus musculus
 Database cross references - Epha5
ExoCarta ExoCarta_13839
Entrez Gene 13839
UniProt Q60629  
 Epha5 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Epha5
Molecular Function
    transmembrane receptor protein tyrosine kinase activity GO:0004714 IEA
    nucleotide binding GO:0000166 IEA
    kinase activity GO:0016301 IEA
    transferase activity GO:0016740 IEA
    transferase activity, transferring phosphorus-containing groups GO:0016772 IEA
    GPI-linked ephrin receptor activity GO:0005004 IDA
    protein binding GO:0005515 IPI
    ephrin receptor activity GO:0005003 ISO
    growth factor receptor binding GO:0070851 ISO
    ATP binding GO:0005524 IEA
    protein tyrosine kinase activity GO:0004713 IEA
    protein kinase activity GO:0004672 IEA
Biological Process
    phosphorylation GO:0016310 IEA
    regulation of GTPase activity GO:0043087 IDA
    nervous system development GO:0007399 IEA
    peptidyl-tyrosine phosphorylation GO:0018108 IDA
    hippocampus development GO:0021766 IDA
    dendritic spine morphogenesis GO:0060997 ISO
    axon guidance GO:0007411 IDA
    negative regulation of synapse assembly GO:0051964 IMP
    positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 ISO
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IEA
    regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061178 IDA
    positive regulation of CREB transcription factor activity GO:0032793 ISO
    regulation of actin cytoskeleton organization GO:0032956 IDA
    cAMP-mediated signaling GO:0019933 ISO
    protein phosphorylation GO:0006468 IEA
    ephrin receptor signaling pathway GO:0048013 ISO
Subcellular Localization
    intracellular GO:0005622 ISO
    neuronal cell body GO:0043025 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    rough endoplasmic reticulum GO:0005791 ISO
    cell projection GO:0042995 IEA
    dendrite GO:0030425 ISO
    plasma membrane GO:0005886 ISO
    membrane GO:0016020 IEA
    integral component of membrane GO:0016021 IEA
    external side of plasma membrane GO:0009897 ISO
 Experiment description of studies that identified Epha5 in exosomes
Experiment ID 15
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
 Protein-protein interactions for Epha5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Epha5 is involved
EPH-ephrin mediated repulsion of cells IEA Reactome
EPH-Ephrin signaling IEA Reactome
EPHA-mediated growth cone collapse IEA Reactome

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here