Gene description for Epha5
Gene name Eph receptor A5
Gene symbol Epha5
Other names/aliases AI854630
AW125296
Cek7
Ehk1
Els1
Hek7
Rek7
bsk
Species Mus musculus
 Database cross references - Epha5
ExoCarta ExoCarta_13839
Vesiclepedia VP_13839
Entrez Gene 13839
UniProt Q60629  
 Epha5 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Epha5
Molecular Function
    transmembrane receptor protein tyrosine kinase activity GO:0004714 IBA
    ephrin receptor activity GO:0005003 ISO
    ephrin receptor activity GO:0005003 ISS
    GPI-linked ephrin receptor activity GO:0005004 IDA
    transmembrane-ephrin receptor activity GO:0005005 IEA
    epidermal growth factor receptor activity GO:0005006 IEA
    fibroblast growth factor receptor activity GO:0005007 IEA
    hepatocyte growth factor receptor activity GO:0005008 IEA
    insulin receptor activity GO:0005009 IEA
    insulin-like growth factor receptor activity GO:0005010 IEA
    macrophage colony-stimulating factor receptor activity GO:0005011 IEA
    platelet-derived growth factor alpha-receptor activity GO:0005018 IEA
    platelet-derived growth factor beta-receptor activity GO:0005019 IEA
    stem cell factor receptor activity GO:0005020 IEA
    vascular endothelial growth factor receptor activity GO:0005021 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    boss receptor activity GO:0008288 IEA
    growth factor binding GO:0019838 ISO
    histone H3Y41 kinase activity GO:0035401 IEA
    placental growth factor receptor activity GO:0036332 IEA
    protein tyrosine kinase collagen receptor activity GO:0038062 IEA
    brain-derived neurotrophic factor receptor activity GO:0060175 IEA
    histone H2AXY142 kinase activity GO:0140801 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    negative regulation of cell adhesion GO:0007162 ISO
    cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA
    epidermal growth factor receptor signaling pathway GO:0007173 IEA
    multicellular organism development GO:0007275 IBA
    axon guidance GO:0007411 IDA
    insulin receptor signaling pathway GO:0008286 IEA
    fibroblast growth factor receptor signaling pathway GO:0008543 IEA
    cAMP-mediated signaling GO:0019933 ISO
    hippocampus development GO:0021766 IDA
    brain-derived neurotrophic factor receptor signaling pathway GO:0031547 IEA
    positive regulation of CREB transcription factor activity GO:0032793 ISS
    regulation of actin cytoskeleton organization GO:0032956 IDA
    platelet-derived growth factor receptor-alpha signaling pathway GO:0035790 IEA
    platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IEA
    vascular endothelial growth factor receptor-1 signaling pathway GO:0036323 IEA
    collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IEA
    vascular endothelial growth factor signaling pathway GO:0038084 IEA
    Kit signaling pathway GO:0038109 IEA
    macrophage colony-stimulating factor signaling pathway GO:0038145 IEA
    regulation of GTPase activity GO:0043087 IDA
    insulin-like growth factor receptor signaling pathway GO:0048009 IEA
    hepatocyte growth factor receptor signaling pathway GO:0048012 IEA
    ephrin receptor signaling pathway GO:0048013 IDA
    ephrin receptor signaling pathway GO:0048013 ISO
    dendritic spine morphogenesis GO:0060997 ISO
    regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061178 IDA
    cellular response to follicle-stimulating hormone stimulus GO:0071372 IDA
    cellular response to forskolin GO:1904322 IDA
Subcellular Localization
    rough endoplasmic reticulum GO:0005791 ISO
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    adherens junction GO:0005912 IDA
    external side of plasma membrane GO:0009897 ISO
    axon GO:0030424 ISO
    axon GO:0030424 ISS
    dendrite GO:0030425 ISO
    dendrite GO:0030425 ISS
    neuronal cell body GO:0043025 ISO
    receptor complex GO:0043235 IBA
    perinuclear region of cytoplasm GO:0048471 ISO
    cell periphery GO:0071944 IDA
 Experiment description of studies that identified Epha5 in sEVs
1
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Epha5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Epha5 is involved
No pathways found





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