Gene description for Ephb2
Gene name Eph receptor B2
Gene symbol Ephb2
Other names/aliases Cek5
Drt
ETECK
Erk
Hek5
Nuk
Prkm5
Qek5
Sek3
Tyro5
Species Mus musculus
 Database cross references - Ephb2
ExoCarta ExoCarta_13844
Vesiclepedia VP_13844
Entrez Gene 13844
 Ephb2 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ephb2
Molecular Function
    ATP binding GO:0005524 IEA
    receptor activity GO:0004872 IDA
    nucleotide binding GO:0000166 IEA
    ephrin receptor activity GO:0005003 IDA
    transmembrane receptor protein tyrosine kinase activity GO:0004714 IEA
    receptor binding GO:0005102 IPI
    identical protein binding GO:0042802 IPI
    kinase activity GO:0016301 IEA
    transferase activity, transferring phosphorus-containing groups GO:0016772 IEA
    transmembrane-ephrin receptor activity GO:0005005 TAS
    axon guidance receptor activity GO:0008046 IDA
    protein binding GO:0005515 IPI
    protein tyrosine kinase activity GO:0004713 IDA
    protein kinase activity GO:0004672 IEA
    transferase activity GO:0016740 IEA
Biological Process
    axon guidance GO:0007411 IMP
    central nervous system projection neuron axonogenesis GO:0021952 IMP
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IDA
    cell morphogenesis GO:0000902 IGI
    positive regulation of synapse assembly GO:0051965 IMP
    protein phosphorylation GO:0006468 IDA
    palate development GO:0060021 IMP
    positive regulation of long-term neuronal synaptic plasticity GO:0048170 IMP
    multicellular organismal development GO:0007275 IEA
    nervous system development GO:0007399 IEA
    corpus callosum development GO:0022038 IMP
    dendritic spine morphogenesis GO:0060997 IMP
    peptidyl-tyrosine phosphorylation GO:0018108 TAS
    commissural neuron axon guidance GO:0071679 IMP
    phosphorylation GO:0016310 IDA
    retinal ganglion cell axon guidance GO:0031290 IDA
    regulation of neuronal synaptic plasticity GO:0048168 IMP
    regulation of body fluid levels GO:0050878 IMP
    organ morphogenesis GO:0009887 IMP
    angiogenesis GO:0001525 IMP
    camera-type eye morphogenesis GO:0048593 IMP
    negative regulation of axonogenesis GO:0050771 IDA
    urogenital system development GO:0001655 IMP
    ephrin receptor signaling pathway GO:0048013 TAS
    dendritic spine development GO:0060996 IMP
    inner ear morphogenesis GO:0042472 IMP
    learning GO:0007612 IMP
    regulation of axonogenesis GO:0050770 IDA
    optic nerve morphogenesis GO:0021631 IMP
    axonal fasciculation GO:0007413 IMP
Subcellular Localization
    dendrite GO:0030425 IDA
    cell projection GO:0042995 IEA
    membrane GO:0016020 IEA
    axon GO:0030424 IDA
    plasma membrane GO:0005886 IEA
    integral component of membrane GO:0016021 IEA
    synapse GO:0045202 NAS
    neuronal cell body GO:0043025 IDA
    integral component of plasma membrane GO:0005887 TAS
 Experiment description of studies that identified Ephb2 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ephb2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ephb2 is involved
No pathways found





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