Gene description for Nr2f1
Gene name nuclear receptor subfamily 2, group F, member 1
Gene symbol Nr2f1
Other names/aliases COUP-TF1
COUP-TFI
COUPTFA
EAR3
Erbal3
SVP44
Tcfcoup1
Species Mus musculus
 Database cross references - Nr2f1
ExoCarta ExoCarta_13865
Entrez Gene 13865
UniProt Q60632  
 Nr2f1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Nr2f1
Molecular Function
    DNA binding GO:0003677 IEA
    retinoic acid-responsive element binding GO:0044323 ISO
    ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0004879 IEA
    sequence-specific DNA binding GO:0043565 ISO
    metal ion binding GO:0046872 IEA
    zinc ion binding GO:0008270 IEA
    steroid hormone receptor activity GO:0003707 IEA
    sequence-specific DNA binding transcription factor activity GO:0003700 ISO
Biological Process
    cerebral cortex regionalization GO:0021796 IMP
    nervous system development GO:0007399 ISO
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    positive regulation of receptor biosynthetic process GO:0010870 ISO
    forebrain development GO:0030900 IDA
    negative regulation of neuron projection development GO:0010977 ISO
    transcription, DNA-templated GO:0006351 IEA
    steroid hormone mediated signaling pathway GO:0043401 IEA
    neuron migration GO:0001764 IDA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    regulation of transcription, DNA-templated GO:0006355 IEA
Subcellular Localization
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Nr2f1 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Nr2f1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Nr2f1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here