Gene description for Nr2f1
Gene name nuclear receptor subfamily 2, group F, member 1
Gene symbol Nr2f1
Other names/aliases COUP-TF1
COUP-TFI
COUPTFA
EAR3
Erbal3
SVP44
Tcfcoup1
Species Mus musculus
 Database cross references - Nr2f1
ExoCarta ExoCarta_13865
Vesiclepedia VP_13865
Entrez Gene 13865
UniProt Q60632  
 Nr2f1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Nr2f1
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 ISO
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 ISO
    DNA-binding transcription factor activity GO:0003700 IEA
    DNA-binding transcription factor activity GO:0003700 ISO
    nuclear receptor activity GO:0004879 IBA
    zinc ion binding GO:0008270 IEA
    sequence-specific DNA binding GO:0043565 IDA
    sequence-specific DNA binding GO:0043565 ISO
    retinoic acid-responsive element binding GO:0044323 ISO
    sequence-specific double-stranded DNA binding GO:1990837 ISO
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IBA
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    neuron migration GO:0001764 IDA
    nervous system development GO:0007399 IBA
    nervous system development GO:0007399 ISO
    regulation of gene expression GO:0010468 IGI
    negative regulation of neuron projection development GO:0010977 ISO
    cerebral cortex regionalization GO:0021796 IMP
    cell differentiation GO:0030154 IBA
    forebrain development GO:0030900 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    positive regulation of miRNA transcription GO:1902895 IMP
    interneuron migration GO:1904936 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Nr2f1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Nr2f1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NCOR2  
Reconstituted Complex Homo sapiens
View the network image/svg+xml



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