Gene description for Amz2
Gene name archaelysin family metallopeptidase 2
Gene symbol Amz2
Other names/aliases AA408420
ESTM12
X83328
Species Mus musculus
 Database cross references - Amz2
ExoCarta ExoCarta_13929
Entrez Gene 13929
UniProt Q400C8  
 Amz2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Amz2
Molecular Function
    cysteine-type peptidase activity GO:0008234 IEA
    molecular_function GO:0003674 ND
    zinc ion binding GO:0008270 IEA
    hydrolase activity GO:0016787 IEA
    metallopeptidase activity GO:0008237 IEA
    peptidase activity GO:0008233 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    biological_process GO:0008150 ND
    proteolysis GO:0006508 IEA
Subcellular Localization
    cellular_component GO:0005575 ND
 Experiment description of studies that identified Amz2 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Amz2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Amz2 is involved
No pathways found





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