Gene description for Chchd2
Gene name coiled-coil-helix-coiled-coil-helix domain containing 2
Gene symbol Chchd2
Other names/aliases AL033347
Etohi6
Species Mus musculus
 Database cross references - Chchd2
ExoCarta ExoCarta_14004
Vesiclepedia VP_14004
Entrez Gene 14004
UniProt Q9D1L0  
 Chchd2 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Chchd2
Molecular Function
    sequence-specific DNA binding GO:0043565 IBA
    sequence-specific DNA binding GO:0043565 ISO
    sequence-specific DNA binding GO:0043565 ISS
    DNA-binding transcription factor binding GO:0140297 ISO
    DNA-binding transcription factor binding GO:0140297 ISS
Biological Process
    mitochondrion organization GO:0007005 IBA
    mitochondrion organization GO:0007005 IEA
    cellular response to oxidative stress GO:0034599 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
    positive regulation of transcription by RNA polymerase II GO:0045944 ISS
    regulation of cellular response to hypoxia GO:1900037 ISS
    positive regulation of mitochondrial ATP synthesis coupled electron transport GO:1905448 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 ISO
    mitochondrial intermembrane space GO:0005758 ISO
    mitochondrial intermembrane space GO:0005758 ISS
 Experiment description of studies that identified Chchd2 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Chchd2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Htt  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Chchd2 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here