Gene description for Elmo1
Gene name engulfment and cell motility 1
Gene symbol Elmo1
Other names/aliases 6330578D22Rik
C230095H21Rik
CED-12
Species Mus musculus
 Database cross references - Elmo1
ExoCarta ExoCarta_140580
Vesiclepedia VP_140580
Entrez Gene 140580
UniProt Q8BPU7  
 Elmo1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Elmo1
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IEA
    guanyl-nucleotide exchange factor activity GO:0005085 ISO
    protein binding GO:0005515 IPI
    SH3 domain binding GO:0017124 IEA
    SH3 domain binding GO:0017124 ISO
Biological Process
    phagocytosis GO:0006909 IDA
    phagocytosis, engulfment GO:0006911 ISO
    phagocytosis, engulfment GO:0006911 ISS
    apoptotic process GO:0006915 IEA
    actin filament organization GO:0007015 IBA
    Rac protein signal transduction GO:0016601 ISO
    Rac protein signal transduction GO:0016601 ISS
    actin filament-based process GO:0030029 IDA
    actin cytoskeleton organization GO:0030036 ISO
    actin cytoskeleton organization GO:0030036 ISS
    cell motility GO:0048870 IBA
    cell motility GO:0048870 ISO
    cell motility GO:0048870 ISS
    regulation of postsynapse assembly GO:0150052 IEA
Subcellular Localization
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    guanyl-nucleotide exchange factor complex GO:0032045 IBA
    guanyl-nucleotide exchange factor complex GO:0032045 IDA
    guanyl-nucleotide exchange factor complex GO:0032045 ISO
    postsynapse GO:0098794 IDA
    postsynapse GO:0098794 IMP
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IMP
 Experiment description of studies that identified Elmo1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Elmo1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Bai1  
Co-fractionation Mus musculus
2 Mapt  
Affinity Capture-MS Mus musculus
3 Atg16l1  
Affinity Capture-MS Mus musculus
4 Elmo3  
Co-fractionation Mus musculus
5 APBB1  
Two-hybrid Homo sapiens
6 Fancd2  
Affinity Capture-MS Mus musculus
View the network image/svg+xml



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