Gene description for Srsf10
Gene name serine/arginine-rich splicing factor 10
Gene symbol Srsf10
Other names/aliases FUSIP2
Fusip1
NSSR1
NSSR2
Nssr
SRrp40
Sfrs13a
Srsf13a
TASR
TASR1
TASR2
Species Mus musculus
 Database cross references - Srsf10
ExoCarta ExoCarta_14105
Vesiclepedia VP_14105
Entrez Gene 14105
UniProt Q9R0U0  
 Srsf10 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
Mast cells 17486113    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Srsf10
Molecular Function
    unfolded protein binding GO:0051082 NAS
    poly(A) RNA binding GO:0044822 ISO
    nucleic acid binding GO:0003676 IEA
    nucleotide binding GO:0000166 IEA
    RNA binding GO:0003723 NAS
Biological Process
    mRNA processing GO:0006397 IEA
    cytoplasmic transport GO:0016482 ISO
    negative regulation of mRNA splicing, via spliceosome GO:0048025 ISO
    regulation of transcription, DNA-templated GO:0006355 NAS
    RNA splicing, via transesterification reactions GO:0000375 ISO
    mRNA splicing, via spliceosome GO:0000398 ISO
    mRNA export from nucleus GO:0006406 NAS
    RNA splicing GO:0008380 IEA
    mRNA splice site selection GO:0006376 ISO
Subcellular Localization
    cell GO:0005623 NAS
    nucleoplasm GO:0005654 ISO
    intracellular GO:0005622 NAS
    nucleus GO:0005634 IEA
 Experiment description of studies that identified Srsf10 in exosomes
1
Experiment ID 907
MISEV standards
EM
EV Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
HSPA5
EV Negative markers
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 15
MISEV standards
EM
EV Biophysical techniques
CD63
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
3
Experiment ID 908
MISEV standards
EM
EV Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
HSPA5
EV Negative markers
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Srsf10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fus  
Affinity Capture-Western Mus musculus
Two-hybrid Mus musculus
View the network image/svg+xml
 Pathways in which Srsf10 is involved
No pathways found





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