Gene description for Fcer1g
Gene name Fc receptor, IgE, high affinity I, gamma polypeptide
Gene symbol Fcer1g
Other names/aliases AI573376
CD23
FcR-gamma
FcR[g]
FcRgamma
Fce1g
FcepsilonRI
Ly-50
Species Mus musculus
 Database cross references - Fcer1g
ExoCarta ExoCarta_14127
Vesiclepedia VP_14127
Entrez Gene 14127
UniProt P20491  
 Fcer1g identified in sEVs derived from the following tissue/cell type
Microglia 16081791    
 Gene ontology annotations for Fcer1g
Molecular Function
    protein binding GO:0005515 IPI
    IgE receptor activity GO:0019767 IBA
    IgE receptor activity GO:0019767 IDA
    IgE receptor activity GO:0019767 IMP
    IgE binding GO:0019863 IDA
    IgE binding GO:0019863 IDA
    IgE binding GO:0019863 IMP
    IgG binding GO:0019864 IBA
    IgG binding GO:0019864 IMP
    identical protein binding GO:0042802 IPI
    identical protein binding GO:0042802 ISO
    protein homodimerization activity GO:0042803 ISO
    metal ion binding GO:0046872 IEA
    protein heterodimerization activity GO:0046982 ISO
Biological Process
    positive regulation of type IIa hypersensitivity GO:0001798 IMP
    positive regulation of type III hypersensitivity GO:0001805 IMP
    positive regulation of type I hypersensitivity GO:0001812 IMP
    neutrophil activation involved in immune response GO:0002283 IBA
    neutrophil activation involved in immune response GO:0002283 IMP
    T cell differentiation involved in immune response GO:0002292 IBA
    T cell differentiation involved in immune response GO:0002292 IMP
    Fc receptor mediated stimulatory signaling pathway GO:0002431 IBA
    Fc receptor mediated stimulatory signaling pathway GO:0002431 IMP
    serotonin secretion by platelet GO:0002554 IMP
    phagocytosis, engulfment GO:0006911 IMP
    signal transduction GO:0007165 IDA
    cell surface receptor signaling pathway GO:0007166 IEP
    cell surface receptor signaling pathway GO:0007166 IMP
    integrin-mediated signaling pathway GO:0007229 IMP
    regulation of platelet activation GO:0010543 IBA
    regulation of platelet activation GO:0010543 IMP
    immunoglobulin mediated immune response GO:0016064 IBA
    immunoglobulin mediated immune response GO:0016064 IMP
    antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 IBA
    antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 IMP
    osteoclast differentiation GO:0030316 IMP
    neutrophil chemotaxis GO:0030593 IBA
    neutrophil chemotaxis GO:0030593 IMP
    receptor internalization GO:0031623 IDA
    interleukin-2 production GO:0032623 IPI
    interleukin-6 production GO:0032635 IDA
    interleukin-6 production GO:0032635 IMP
    tumor necrosis factor production GO:0032640 IDA
    tumor necrosis factor production GO:0032640 IMP
    positive regulation of interleukin-10 production GO:0032733 IMP
    positive regulation of interleukin-4 production GO:0032753 IMP
    positive regulation of interleukin-6 production GO:0032755 IDA
    positive regulation of interleukin-6 production GO:0032755 IMP
    positive regulation of tumor necrosis factor production GO:0032760 IDA
    positive regulation of tumor necrosis factor production GO:0032760 IMP
    mast cell cytokine production GO:0032762 IDA
    mast cell cytokine production GO:0032762 IMP
    positive regulation of mast cell cytokine production GO:0032765 IDA
    positive regulation of mast cell cytokine production GO:0032765 IMP
    mast cell apoptotic process GO:0033024 IDA
    mast cell apoptotic process GO:0033024 IMP
    negative regulation of mast cell apoptotic process GO:0033026 IDA
    negative regulation of mast cell apoptotic process GO:0033026 IMP
    Fc-gamma receptor signaling pathway GO:0038094 IBA
    Fc-gamma receptor signaling pathway GO:0038094 IDA
    Fc-epsilon receptor signaling pathway GO:0038095 IEA
    Fc-epsilon receptor signaling pathway GO:0038095 ISO
    interleukin-3-mediated signaling pathway GO:0038156 IMP
    antigen processing and presentation of exogenous peptide antigen via MHC class I GO:0042590 IBA
    antigen processing and presentation of exogenous peptide antigen via MHC class I GO:0042590 IMP
    defense response to bacterium GO:0042742 IBA
    defense response to bacterium GO:0042742 IMP
    mast cell degranulation GO:0043303 IDA
    mast cell degranulation GO:0043303 IMP
    positive regulation of mast cell degranulation GO:0043306 IDA
    positive regulation of mast cell degranulation GO:0043306 IMP
    innate immune response GO:0045087 IBA
    innate immune response GO:0045087 IMP
    mast cell activation GO:0045576 IDA
    mast cell activation GO:0045576 IMP
    positive regulation of phagocytosis GO:0050766 IBA
    positive regulation of phagocytosis GO:0050766 IMP
    regulation of immune response GO:0050776 IMP
    positive regulation of immune response GO:0050778 IMP
    cellular response to low-density lipoprotein particle stimulus GO:0071404 IDA
    protein localization to plasma membrane GO:0072659 IDA
    positive regulation of protein localization to cell surface GO:2000010 IDA
    positive regulation of protein localization to cell surface GO:2000010 IMP
Subcellular Localization
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IBA
    external side of plasma membrane GO:0009897 IDA
    cell surface GO:0009986 IDA
    cell surface GO:0009986 ISO
    Fc-epsilon receptor I complex GO:0032998 IBA
    Fc-epsilon receptor I complex GO:0032998 IMP
    Fc-gamma receptor III complex GO:0033001 ISO
    membrane raft GO:0045121 TAS
 Experiment description of studies that identified Fcer1g in sEVs
1
Experiment ID 14
MISEV standards
EM
Biophysical techniques
RAB7|RAB11|CD9|CD63|LAMP1|LAMP2
Enriched markers
DNM
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 16081791    
Organism Mus musculus
Experiment description Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism.
Authors "Potolicchio I, Carven GJ, Xu X, Stipp C, Riese RJ, Stern LJ, Santambrogio L"
Journal name JIMMU
Publication year 2005
Sample Microglia
Sample name N9
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
 Protein-protein interactions for Fcer1g
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tmem173  
Proximity Label-MS Mus musculus
View the network image/svg+xml



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