Gene description for Fcgr1
Gene name Fc receptor, IgG, high affinity I
Gene symbol Fcgr1
Other names/aliases AI323638
AV092959
CD64
FcgammaRI
IGGHAFC
Species Mus musculus
 Database cross references - Fcgr1
ExoCarta ExoCarta_14129
Entrez Gene 14129
UniProt P26151  
 Fcgr1 identified in exosomes derived from the following tissue/cell type
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
 Gene ontology annotations for Fcgr1
Molecular Function
    IgG binding GO:0019864 IMP
    leukotriene receptor binding GO:0031774 ISO
    IgG receptor activity GO:0019770 IMP
Biological Process
    positive regulation of phagocytosis GO:0050766 IMP
    antigen processing and presentation of exogenous antigen GO:0019884 IMP
    immune system process GO:0002376 IEA
    regulation of immune response GO:0050776 IMP
    phagocytosis, engulfment GO:0006911 IMP
    positive regulation of phagocytosis, engulfment GO:0060100 ISO
    antigen processing and presentation of exogenous peptide antigen via MHC class I GO:0042590 IMP
    phagocytosis, recognition GO:0006910 IMP
    cell surface receptor signaling pathway GO:0007166 IMP
    positive regulation of type III hypersensitivity GO:0001805 IMP
    receptor-mediated endocytosis GO:0006898 IMP
    positive regulation of type IIa hypersensitivity GO:0001798 IMP
    defense response to bacterium GO:0042742 IMP
    response to bacterium GO:0009617 IMP
    innate immune response GO:0045087 IEA
    antibody-dependent cellular cytotoxicity GO:0001788 IMP
    Fc-gamma receptor signaling pathway GO:0038094 IMP
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    membrane raft GO:0045121 ISO
    plasma membrane GO:0005886 ISO
    membrane GO:0016020 IEA
    external side of plasma membrane GO:0009897 IDA
 Experiment description of studies that identified Fcgr1 in exosomes
1
Experiment ID 214
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 215
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 216
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Fcgr1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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