Gene description for Fcgr1
Gene name Fc receptor, IgG, high affinity I
Gene symbol Fcgr1
Other names/aliases AI323638
AV092959
CD64
FcgammaRI
IGGHAFC
Species Mus musculus
 Database cross references - Fcgr1
ExoCarta ExoCarta_14129
Vesiclepedia VP_14129
Entrez Gene 14129
UniProt P26151  
 Fcgr1 identified in sEVs derived from the following tissue/cell type
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
 Gene ontology annotations for Fcgr1
Molecular Function
    IgG receptor activity GO:0019770 IBA
    IgG receptor activity GO:0019770 IMP
    high-affinity IgG receptor activity GO:0019771 IEA
    high-affinity IgG receptor activity GO:0019771 ISO
    IgG binding GO:0019864 IBA
    IgG binding GO:0019864 IDA
    IgG binding GO:0019864 IMP
    leukotriene receptor binding GO:0031774 ISO
Biological Process
    antibody-dependent cellular cytotoxicity GO:0001788 IBA
    antibody-dependent cellular cytotoxicity GO:0001788 IMP
    positive regulation of type IIa hypersensitivity GO:0001798 IMP
    positive regulation of type III hypersensitivity GO:0001805 IMP
    receptor-mediated endocytosis GO:0006898 IMP
    phagocytosis, recognition GO:0006910 IMP
    phagocytosis, engulfment GO:0006911 IMP
    cell surface receptor signaling pathway GO:0007166 IBA
    cell surface receptor signaling pathway GO:0007166 IMP
    response to bacterium GO:0009617 IMP
    antigen processing and presentation of exogenous antigen GO:0019884 IMP
    positive regulation of tumor necrosis factor production GO:0032760 IBA
    Fc-gamma receptor signaling pathway GO:0038094 IEA
    antigen processing and presentation of exogenous peptide antigen via MHC class I GO:0042590 IMP
    defense response to bacterium GO:0042742 IMP
    innate immune response GO:0045087 IEA
    positive regulation of phagocytosis GO:0050766 IBA
    positive regulation of phagocytosis GO:0050766 IMP
    regulation of immune response GO:0050776 IMP
    positive regulation of phagocytosis, engulfment GO:0060100 ISO
Subcellular Localization
    plasma membrane GO:0005886 ISO
    external side of plasma membrane GO:0009897 IBA
    external side of plasma membrane GO:0009897 IDA
 Experiment description of studies that identified Fcgr1 in sEVs
1
Experiment ID 214
MISEV standards
EM
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 215
MISEV standards
EM
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 216
MISEV standards
EM
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Fcgr1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Zbtb7b  
Affinity Capture-MS Mus musculus
2 Kctd13  
Affinity Capture-MS Mus musculus
3 Tmem173  
Proximity Label-MS Mus musculus
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here