Gene description for Akr1b8
Gene name aldo-keto reductase family 1, member B8
Gene symbol Akr1b8
Other names/aliases FR-1
Fgfrp
Fgrp
Species Mus musculus
 Database cross references - Akr1b8
ExoCarta ExoCarta_14187
Vesiclepedia VP_14187
Entrez Gene 14187
UniProt P45377  
 Akr1b8 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Akr1b8
Molecular Function
    retinal dehydrogenase activity GO:0001758 ISO
    aldose reductase (NADPH) activity GO:0004032 IBA
    aldose reductase (NADPH) activity GO:0004032 IEA
    aldose reductase (NADPH) activity GO:0004032 ISO
    estradiol 17-beta-dehydrogenase [NAD(P)+] activity GO:0004303 ISO
    alcohol dehydrogenase (NADP+) activity GO:0008106 ISO
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 ISO
    retinal binding GO:0016918 ISO
    geranylgeranyl reductase activity GO:0045550 ISO
    indanol dehydrogenase activity GO:0047718 ISO
    all-trans-retinol dehydrogenase (NADP+) activity GO:0052650 ISO
    NADP+ binding GO:0070401 ISO
    NADPH binding GO:0070402 ISO
Subcellular Localization
    extracellular region GO:0005576 ISO
    cytoplasm GO:0005737 IEA
    mitochondrion GO:0005739 ISO
    lysosome GO:0005764 ISO
    cytosol GO:0005829 IBA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Akr1b8 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Akr1b8
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here