Gene description for Gba
Gene name glucosidase, beta, acid
Gene symbol Gba
Other names/aliases GBA1
Species Mus musculus
 Database cross references - Gba
ExoCarta ExoCarta_14466
Entrez Gene 14466
UniProt P17439  
 Gba identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Gba
Molecular Function
    glucosylceramidase activity GO:0004348 ISO
    hydrolase activity, acting on glycosyl bonds GO:0016798 IEA
    hydrolase activity GO:0016787 IEA
    receptor binding GO:0005102 IPI
Biological Process
    response to thyroid hormone GO:0097066 ISO
    ceramide biosynthetic process GO:0046513 ISO
    carbohydrate metabolic process GO:0005975 IEA
    negative regulation of MAP kinase activity GO:0043407 ISO
    response to pH GO:0009268 ISO
    response to glucocorticoid GO:0051384 ISO
    cellular response to tumor necrosis factor GO:0071356 ISO
    positive regulation of protein dephosphorylation GO:0035307 ISO
    positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 ISO
    response to estrogen GO:0043627 ISO
    skin morphogenesis GO:0043589 ISO
    sphingolipid metabolic process GO:0006665 IEA
    response to testosterone GO:0033574 ISO
    sphingosine biosynthetic process GO:0046512 ISO
    termination of signal transduction GO:0023021 ISO
    negative regulation of interleukin-6 production GO:0032715 ISO
    lipid metabolic process GO:0006629 IEA
    regulation of water loss via skin GO:0033561 ISO
    metabolic process GO:0008152 IEA
    glucosylceramide catabolic process GO:0006680 ISO
Subcellular Localization
    lysosomal membrane GO:0005765 ISO
    lysosomal lumen GO:0043202 IDA
    membrane GO:0016020 IEA
    extracellular exosome GO:0070062 ISO
    lysosome GO:0005764 IEA
 Experiment description of studies that identified Gba in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Gba
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Gba is involved
Glycosphingolipid metabolism IEA Reactome

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