Gene description for Gba
Gene name	glucosidase, beta, acid
Gene symbol	Gba
Other names/aliases	GBA1 GC GCase GLUC betaGC
Species	Mus musculus
Database cross references - Gba
ExoCarta	ExoCarta_14466
Vesiclepedia	VP_14466
Entrez Gene	14466
UniProt	P17439
Gba identified in sEVs derived from the following tissue/cell type
Fibroblasts	23260141

Gene ontology annotations for Gba

Molecular Function     galactosylceramidase activity GO:0004336 IEA     glucosylceramidase activity GO:0004348 IBA     glucosylceramidase activity GO:0004348 IDA     glucosylceramidase activity GO:0004348 IMP     glucosylceramidase activity GO:0004348 ISO     signaling receptor binding GO:0005102 IPI     scavenger receptor binding GO:0005124 IEA     scavenger receptor binding GO:0005124 ISO     protein binding GO:0005515 IPI     beta-glucosidase activity GO:0008422 IDA     beta-glucosidase activity GO:0008422 IMP     hydrolase activity GO:0016787 IDA     glucosyltransferase activity GO:0046527 IDA     glucosyltransferase activity GO:0046527 ISO     steryl-beta-glucosidase activity GO:0050295 ISO     steryl-beta-glucosidase activity GO:0050295 ISS Biological Process     mitophagy GO:0000423 IMP     glucosylceramide metabolic process GO:0006678 IMP     glucosylceramide catabolic process GO:0006680 IBA     glucosylceramide catabolic process GO:0006680 IDA     glucosylceramide catabolic process GO:0006680 IMP     glucosylceramide catabolic process GO:0006680 ISO     autophagy GO:0006914 IMP     autophagy GO:0006914 IMP     autophagy GO:0006914 ISO     autophagy GO:0006914 ISS     mitochondrion organization GO:0007005 IMP     lysosome organization GO:0007040 IMP     lysosome organization GO:0007040 ISO     lysosome organization GO:0007040 ISS     central nervous system development GO:0007417 IMP     cholesterol metabolic process GO:0008203 IDA     cholesterol metabolic process GO:0008203 IEA     cholesterol metabolic process GO:0008203 ISO     determination of adult lifespan GO:0008340 IMP     cellular response to starvation GO:0009267 IMP     response to pH GO:0009268 IEA     response to pH GO:0009268 ISO     microglia differentiation GO:0014004 IMP     antigen processing and presentation GO:0019882 IMP     lipid storage GO:0019915 IMP     cerebellar Purkinje cell layer formation GO:0021694 IMP     pyramidal neuron differentiation GO:0021859 IMP     respiratory electron transport chain GO:0022904 IMP     termination of signal transduction GO:0023021 IEA     termination of signal transduction GO:0023021 ISO     lipid glycosylation GO:0030259 IDA     lipid glycosylation GO:0030259 ISO     negative regulation of protein-containing complex assembly GO:0031333 IMP     negative regulation of protein-containing complex assembly GO:0031333 ISO     regulation of TOR signaling GO:0032006 IMP     regulation of TOR signaling GO:0032006 ISO     regulation of TOR signaling GO:0032006 ISS     positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IMP     negative regulation of interleukin-6 production GO:0032715 IEA     negative regulation of interleukin-6 production GO:0032715 ISO     T cell differentiation in thymus GO:0033077 IMP     response to testosterone GO:0033574 IEA     response to testosterone GO:0033574 ISO     T-helper 2 cell cytokine production GO:0035745 IMP     regulation of membrane potential GO:0042391 IMP     proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IMP     positive regulation of protein-containing complex disassembly GO:0043243 IEA     positive regulation of protein-containing complex disassembly GO:0043243 ISO     negative regulation of MAP kinase activity GO:0043407 ISO     negative regulation of MAPK cascade GO:0043409 IEA     negative regulation of neuron apoptotic process GO:0043524 IMP     response to estrogen GO:0043627 IEA     response to estrogen GO:0043627 ISO     sphingosine biosynthetic process GO:0046512 IEA     sphingosine biosynthetic process GO:0046512 ISO     ceramide biosynthetic process GO:0046513 IEA     ceramide biosynthetic process GO:0046513 ISO     cell maturation GO:0048469 IMP     brain morphogenesis GO:0048854 IMP     homeostasis of number of cells GO:0048872 IMP     nervous system process GO:0050877 IMP     neuromuscular process GO:0050905 IMP     regulation of protein metabolic process GO:0051246 IMP     negative regulation of protein metabolic process GO:0051248 IMP     neuron apoptotic process GO:0051402 IMP     establishment of skin barrier GO:0061436 IEA     establishment of skin barrier GO:0061436 ISO     microglial cell proliferation GO:0061518 IMP     motor behavior GO:0061744 IMP     cellular response to tumor necrosis factor GO:0071356 IEA     cellular response to tumor necrosis factor GO:0071356 ISO     hematopoietic stem cell proliferation GO:0071425 IMP     response to dexamethasone GO:0071548 IEA     response to dexamethasone GO:0071548 ISO     lymphocyte migration GO:0072676 IMP     response to thyroid hormone GO:0097066 IEA     response to thyroid hormone GO:0097066 ISO     skin epidermis development GO:0098773 ISO     beta-glucoside catabolic process GO:1901805 IEA     beta-glucoside catabolic process GO:1901805 ISO     positive regulation of proteolysis involved in protein catabolic process GO:1903052 IMP     positive regulation of protein lipidation GO:1903061 IEA     positive regulation of protein lipidation GO:1903061 ISO     positive regulation of neuronal action potential GO:1904457 IEA     positive regulation of neuronal action potential GO:1904457 ISO     autophagosome organization GO:1905037 IMP     positive regulation of type 2 mitophagy GO:1905091 IMP Subcellular Localization     extracellular space GO:0005615 IDA     lysosome GO:0005764 IDA     lysosome GO:0005764 ISO     lysosomal membrane GO:0005765 IDA     lysosomal membrane GO:0005765 ISO     endoplasmic reticulum GO:0005783 IDA     Golgi apparatus GO:0005794 IDA     trans-Golgi network GO:0005802 IDA     lysosomal lumen GO:0043202 IDA