Gene description for Gpd1
Gene name glycerol-3-phosphate dehydrogenase 1 (soluble)
Gene symbol Gpd1
Other names/aliases AI747587
Gdc-1
Gdc1
mKIAA4010
Species Mus musculus
 Database cross references - Gpd1
ExoCarta ExoCarta_14555
Entrez Gene 14555
UniProt P13707  
 Gpd1 identified in exosomes derived from the following tissue/cell type
Oligodendrocytes 21136642    
 Gene ontology annotations for Gpd1
Molecular Function
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 IEA
    oxidoreductase activity GO:0016491 IEA
    glycerol-3-phosphate dehydrogenase [NAD+] activity GO:0004367 ISO
    glycerol-3-phosphate dehydrogenase activity GO:0004368 ISO
    NAD binding GO:0051287 ISO
    protein homodimerization activity GO:0042803 IEA
Biological Process
    carbohydrate metabolic process GO:0005975 ISO
    glycerol-3-phosphate metabolic process GO:0006072 ISO
    cellular response to tumor necrosis factor GO:0071356 IDA
    cellular response to cAMP GO:0071320 IDA
    glycerophosphate shuttle GO:0006127 IMP
    positive regulation of glycolytic process GO:0045821 IMP
    glycerol-3-phosphate catabolic process GO:0046168 IEA
    gluconeogenesis GO:0006094 IMP
    glycerolipid metabolic process GO:0046486 ISO
    NADH metabolic process GO:0006734 ISO
    NADH oxidation GO:0006116 ISO
    oxidation-reduction process GO:0055114 IDA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    mitochondrion GO:0005739 IDA
    cytosol GO:0005829 ISO
    cell GO:0005623 IMP
    intracellular GO:0005622 IMP
    extracellular exosome GO:0070062 ISO
    glycerol-3-phosphate dehydrogenase complex GO:0009331 TAS
 Experiment description of studies that identified Gpd1 in exosomes
1
Experiment ID 33
ISEV standards
EM|IEM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Gpd1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Gpd1 is involved
PathwayEvidenceSource
Synthesis of PA IEA Reactome
Triglyceride Biosynthesis IEA Reactome





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