Gene description for Gpd1
Gene name glycerol-3-phosphate dehydrogenase 1 (soluble)
Gene symbol Gpd1
Other names/aliases AI747587
Gdc-1
Gdc1
mKIAA4010
Species Mus musculus
 Database cross references - Gpd1
ExoCarta ExoCarta_14555
Vesiclepedia VP_14555
Entrez Gene 14555
UniProt P13707  
 Gpd1 identified in sEVs derived from the following tissue/cell type
Oligodendrocytes 21136642    
 Gene ontology annotations for Gpd1
Molecular Function
    glycerol-3-phosphate dehydrogenase (quinone) activity GO:0004368 IEA
    glycerol-3-phosphate dehydrogenase (quinone) activity GO:0004368 ISO
    protein homodimerization activity GO:0042803 IEA
    glycerol-3-phosphate dehydrogenase [NAD(P)+] activity GO:0047952 IDA
    NAD binding GO:0051287 IEA
    NAD binding GO:0051287 ISO
    glycerol-3-phosphate dehydrogenase (NAD+) activity GO:0141152 IEA
Biological Process
    glycerol-3-phosphate metabolic process GO:0006072 IBA
    glycerol-3-phosphate metabolic process GO:0006072 IMP
    glycerol-3-phosphate metabolic process GO:0006072 ISO
    gluconeogenesis GO:0006094 IMP
    NADH oxidation GO:0006116 IBA
    NADH oxidation GO:0006116 IMP
    NADH oxidation GO:0006116 ISO
    glycerophosphate shuttle GO:0006127 IMP
    glycerophosphate shuttle GO:0006127 IMP
    NADH metabolic process GO:0006734 ISO
    positive regulation of glycolytic process GO:0045821 IMP
    glyceraldehyde-3-phosphate biosynthetic process GO:0046166 ISO
    glycerol-3-phosphate catabolic process GO:0046168 IEA
    glycerolipid metabolic process GO:0046486 IEA
    glycerolipid metabolic process GO:0046486 ISO
    cellular response to cAMP GO:0071320 IDA
    cellular response to tumor necrosis factor GO:0071356 IDA
Subcellular Localization
    mitochondrion GO:0005739 HDA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified Gpd1 in sEVs
1
Experiment ID 33
MISEV standards
EM|IEM
Biophysical techniques
Alix|TSG101
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors "Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J"
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Gpd1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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