Gene description for Ggps1
Gene name geranylgeranyl diphosphate synthase 1
Gene symbol Ggps1
Other names/aliases 1810026C22Rik
9530089B04Rik
AI843169
C79210
Species Mus musculus
 Database cross references - Ggps1
ExoCarta ExoCarta_14593
Entrez Gene 14593
UniProt Q9WTN0  
 Ggps1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ggps1
Molecular Function
    geranyltranstransferase activity GO:0004337 IDA
    protein geranylgeranyltransferase activity GO:0004661 IEA
    transferase activity GO:0016740 IEA
    agmatine aminopropyltransferase activity GO:0043919 IEA
    1,4-dihydroxy-2-naphthoate octaprenyltransferase activity GO:0046428 IEA
    prenyltransferase activity GO:0004659 IEA
    protoheme IX farnesyltransferase activity GO:0008495 IEA
    (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity GO:0043888 IEA
    ATP dimethylallyltransferase activity GO:0052622 IEA
    metal ion binding GO:0046872 IEA
    4-hydroxybenzoate octaprenyltransferase activity GO:0008412 IEA
    dimethylallyltranstransferase activity GO:0004161 IEA
    cadaverine aminopropyltransferase activity GO:0043918 IEA
    ADP dimethylallyltransferase activity GO:0052623 IEA
    trans-pentaprenyltranstransferase activity GO:0048045 IEA
    farnesyltranstransferase activity GO:0004311 ISO
    protein prenyltransferase activity GO:0008318 IEA
Biological Process
    isoprenoid biosynthetic process GO:0008299 IEA
    isoprenoid metabolic process GO:0006720 ISO
Subcellular Localization
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified Ggps1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ggps1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ggps1 is involved
PathwayEvidenceSource
Activation of gene expression by SREBF (SREBP) IEA Reactome
Cholesterol biosynthesis IEA Reactome





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