Gene description for Ggps1
Gene name geranylgeranyl diphosphate synthase 1
Gene symbol Ggps1
Other names/aliases 1810026C22Rik
9530089B04Rik
AI843169
C79210
Species Mus musculus
 Database cross references - Ggps1
ExoCarta ExoCarta_14593
Vesiclepedia VP_14593
Entrez Gene 14593
UniProt Q9WTN0  
 Ggps1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ggps1
Molecular Function
    dimethylallyltranstransferase activity GO:0004161 IEA
    farnesyltranstransferase activity GO:0004311 IBA
    farnesyltranstransferase activity GO:0004311 ISO
    farnesyltranstransferase activity GO:0004311 ISS
    geranyltranstransferase activity GO:0004337 IDA
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    metal ion binding GO:0046872 IEA
Biological Process
    isoprenoid metabolic process GO:0006720 ISO
    isoprenoid metabolic process GO:0006720 ISS
    isoprenoid biosynthetic process GO:0008299 IBA
    geranyl diphosphate biosynthetic process GO:0033384 IEA
    geranylgeranyl diphosphate biosynthetic process GO:0033386 IEA
    farnesyl diphosphate biosynthetic process GO:0045337 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    Z disc GO:0030018 ISO
    Z disc GO:0030018 ISS
    perinuclear region of cytoplasm GO:0048471 ISO
    perinuclear region of cytoplasm GO:0048471 ISS
 Experiment description of studies that identified Ggps1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ggps1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fitm2  
Positive Genetic Mus musculus
2 Unk  
Affinity Capture-RNA Mus musculus
View the network image/svg+xml
 Pathways in which Ggps1 is involved
PathwayEvidenceSource
Cholesterol biosynthesis IEA Reactome
Metabolism IEA Reactome
Metabolism of lipids IEA Reactome
Metabolism of steroids IEA Reactome





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