Gene description for Ghr
Gene name growth hormone receptor
Gene symbol Ghr
Other names/aliases GHBP
GHR/BP
Species Mus musculus
 Database cross references - Ghr
ExoCarta ExoCarta_14600
Entrez Gene 14600
UniProt P16882  
 Ghr identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ghr
Molecular Function
    growth hormone receptor activity GO:0004903 ISO
    SH2 domain binding GO:0042169 ISO
    cytokine receptor activity GO:0004896 IEA
    peptide hormone binding GO:0017046 ISO
    protein kinase binding GO:0019901 ISO
    growth factor binding GO:0019838 ISO
    protein phosphatase binding GO:0019903 ISO
    protein homodimerization activity GO:0042803 ISO
    protein binding GO:0005515 IPI
Biological Process
    endocytosis GO:0006897 IEA
    JAK-STAT cascade GO:0007259 ISO
    growth hormone receptor signaling pathway GO:0060396 ISO
    activation of MAPK activity GO:0000187 ISO
    creatine metabolic process GO:0006600 IMP
    multicellular organismal metabolic process GO:0044236 ISO
    hormone-mediated signaling pathway GO:0009755 ISO
    2-oxoglutarate metabolic process GO:0006103 IMP
    creatinine metabolic process GO:0046449 IMP
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA
    citrate metabolic process GO:0006101 IMP
    regulation of multicellular organism growth GO:0040014 IDA
    oxaloacetate metabolic process GO:0006107 IMP
    allantoin metabolic process GO:0000255 IMP
    valine metabolic process GO:0006573 IMP
    fatty acid metabolic process GO:0006631 IMP
    cytokine-mediated signaling pathway GO:0019221 ISO
    cellular response to hormone stimulus GO:0032870 ISO
    taurine metabolic process GO:0019530 IMP
    positive regulation of JAK-STAT cascade GO:0046427 ISO
    isoleucine metabolic process GO:0006549 IMP
    response to estradiol GO:0032355 ISO
    insulin-like growth factor receptor signaling pathway GO:0048009 ISO
    activation of Janus kinase activity GO:0042976 ISO
    succinate metabolic process GO:0006105 IMP
    activation of JAK2 kinase activity GO:0042977 ISO
    negative regulation of neuron death GO:1901215 ISO
    positive regulation of multicellular organism growth GO:0040018 ISO
Subcellular Localization
    extracellular space GO:0005615 ISO
    plasma membrane GO:0005886 ISO
    nucleus GO:0005634 ISO
    extracellular region GO:0005576 IEA
    cytoplasm GO:0005737 ISO
    neuronal cell body GO:0043025 ISO
    cell surface GO:0009986 ISO
    growth hormone receptor complex GO:0070195 ISO
    extrinsic component of membrane GO:0019898 IDA
    mitochondrion GO:0005739 ISO
    integral component of membrane GO:0016021 ISO
    membrane GO:0016020 IEA
    integral component of plasma membrane GO:0005887 ISO
    receptor complex GO:0043235 ISO
 Experiment description of studies that identified Ghr in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ghr
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ghr is involved
PathwayEvidenceSource
Growth hormone receptor signaling IEA Reactome
Prolactin receptor signaling IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here