Gene description for Grik1
Gene name glutamate receptor, ionotropic, kainate 1
Gene symbol Grik1
Other names/aliases A830007B11Rik
D16Ium24
D16Ium24e
GluK1
GluK5
Glur-5
Glur5
Glurbeta1
Species Mus musculus
 Database cross references - Grik1
ExoCarta ExoCarta_14805
Vesiclepedia VP_14805
Entrez Gene 14805
 Grik1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Grik1
Molecular Function
    SNARE binding GO:0000149 ISO
    glutamate-gated receptor activity GO:0004970 ISO
    extracellularly glutamate-gated ion channel activity GO:0005234 ISO
    L-glutamate transmembrane transporter activity GO:0005313 IMP
    protein binding GO:0005515 IPI
    kainate selective glutamate receptor activity GO:0015277 IBA
    kainate selective glutamate receptor activity GO:0015277 IDA
    kainate selective glutamate receptor activity GO:0015277 IGI
    kainate selective glutamate receptor activity GO:0015277 IMP
    kainate selective glutamate receptor activity GO:0015277 ISO
    kainate selective glutamate receptor activity GO:0015277 ISS
    glutamate binding GO:0016595 ISO
    glutamate-gated calcium ion channel activity GO:0022849 ISS
    identical protein binding GO:0042802 ISO
    scaffold protein binding GO:0097110 ISO
    ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential GO:0099507 ISO
    heterocyclic compound binding GO:1901363 ISO
    transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315 IBA
Biological Process
    nervous system development GO:0007399 ISO
    gamma-aminobutyric acid secretion GO:0014051 IMP
    positive regulation of gamma-aminobutyric acid secretion GO:0014054 IMP
    L-glutamate transmembrane transport GO:0015813 IEA
    calcium-mediated signaling GO:0019722 IEA
    adult behavior GO:0030534 IMP
    negative regulation of synaptic transmission, GABAergic GO:0032229 ISO
    positive regulation of synaptic transmission, GABAergic GO:0032230 IMP
    positive regulation of synaptic transmission, GABAergic GO:0032230 ISO
    monoatomic ion transmembrane transport GO:0034220 IEA
    ionotropic glutamate receptor signaling pathway GO:0035235 IEA
    ionotropic glutamate receptor signaling pathway GO:0035235 ISO
    synaptic transmission, glutamatergic GO:0035249 IBA
    synaptic transmission, glutamatergic GO:0035249 IGI
    synaptic transmission, glutamatergic GO:0035249 IMP
    regulation of membrane potential GO:0042391 IDA
    regulation of membrane potential GO:0042391 IMP
    regulation of long-term neuronal synaptic plasticity GO:0048169 TAS
    regulation of short-term neuronal synaptic plasticity GO:0048172 ISO
    regulation of short-term neuronal synaptic plasticity GO:0048172 TAS
    behavioral response to pain GO:0048266 IMP
    modulation of chemical synaptic transmission GO:0050804 IBA
    establishment of localization in cell GO:0051649 IMP
    membrane depolarization GO:0051899 IMP
    synaptic transmission, GABAergic GO:0051932 IMP
    negative regulation of synaptic transmission, glutamatergic GO:0051967 IGI
    negative regulation of synaptic transmission, glutamatergic GO:0051967 ISO
    excitatory postsynaptic potential GO:0060079 IGI
    excitatory postsynaptic potential GO:0060079 IMP
    inhibitory postsynaptic potential GO:0060080 IGI
    inhibitory postsynaptic potential GO:0060080 IMP
    modulation of excitatory postsynaptic potential GO:0098815 ISO
    presynaptic modulation of chemical synaptic transmission GO:0099171 IGI
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISO
    ionotropic glutamate receptor complex GO:0008328 IC
    ionotropic glutamate receptor complex GO:0008328 ISO
    postsynaptic density GO:0014069 IDA
    membrane GO:0016020 IDA
    dendrite GO:0030425 IDA
    dendrite GO:0030425 ISO
    kainate selective glutamate receptor complex GO:0032983 IBA
    kainate selective glutamate receptor complex GO:0032983 IPI
    presynaptic membrane GO:0042734 IBA
    presynaptic membrane GO:0042734 IDA
    presynaptic membrane GO:0042734 ISO
    neuronal cell body GO:0043025 ISO
    terminal bouton GO:0043195 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    receptor complex GO:0043235 ISO
    synapse GO:0045202 IDA
    postsynaptic membrane GO:0045211 IEA
    postsynaptic density membrane GO:0098839 IBA
    glutamatergic synapse GO:0098978 ISO
 Experiment description of studies that identified Grik1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
2
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Grik1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Grik2  
Affinity Capture-Western Mus musculus
View the network image/svg+xml
 Pathways in which Grik1 is involved
No pathways found





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