Gene description for Grik1
Gene name glutamate receptor, ionotropic, kainate 1
Gene symbol Grik1
Other names/aliases A830007B11Rik
D16Ium24
D16Ium24e
GluK1
GluK5
Glur-5
Glur5
Glurbeta1
Species Mus musculus
 Database cross references - Grik1
ExoCarta ExoCarta_14805
Entrez Gene 14805
 Grik1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Grik1
Molecular Function
    extracellular-glutamate-gated ion channel activity GO:0005234 ISO
    ionotropic glutamate receptor activity GO:0004970 ISO
    glutamate binding GO:0016595 ISO
    receptor activity GO:0004872 IEA
    voltage-gated cation channel activity GO:0022843 ISO
    ion channel activity GO:0005216 IEA
    protein binding GO:0005515 IPI
    kainate selective glutamate receptor activity GO:0015277 ISO
    drug binding GO:0008144 ISO
    protein homodimerization activity GO:0042803 ISO
Biological Process
    negative regulation of synaptic transmission, glutamatergic GO:0051967 ISO
    behavioral response to pain GO:0048266 IMP
    ion transport GO:0006811 IEA
    adult behavior GO:0030534 IMP
    negative regulation of synaptic transmission, GABAergic GO:0032229 ISO
    transport GO:0006810 IEA
    membrane depolarization GO:0051899 IMP
    ionotropic glutamate receptor signaling pathway GO:0035235 ISO
    regulation of excitatory postsynaptic membrane potential GO:0060079 IMP
    regulation of long-term neuronal synaptic plasticity GO:0048169 TAS
    regulation of membrane potential GO:0042391 IMP
    ion transmembrane transport GO:0034220 ISO
    nervous system development GO:0007399 ISO
    positive regulation of gamma-aminobutyric acid secretion GO:0014054 IMP
    synaptic transmission, glutamatergic GO:0035249 IMP
    positive regulation of synaptic transmission, GABAergic GO:0032230 ISO
    regulation of ion transmembrane transport GO:0034765 ISO
    cation transmembrane transport GO:0098655 ISO
    regulation of short-term neuronal synaptic plasticity GO:0048172 TAS
    regulation of inhibitory postsynaptic membrane potential GO:0060080 IMP
Subcellular Localization
    postsynaptic density GO:0014069 IDA
    plasma membrane GO:0005886 IBA
    dendrite GO:0030425 ISO
    kainate selective glutamate receptor complex GO:0032983 IPI
    presynaptic membrane GO:0042734 IDA
    neuronal postsynaptic density GO:0097481 IDA
    ionotropic glutamate receptor complex GO:0008328 ISO
    terminal bouton GO:0043195 ISO
    cell junction GO:0030054 IEA
    receptor complex GO:0043235 ISO
    integral component of membrane GO:0016021 IEA
    synapse GO:0045202 IDA
    postsynaptic membrane GO:0045211 IBA
    membrane GO:0016020 IDA
    neuronal cell body GO:0043025 ISO
 Experiment description of studies that identified Grik1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
2
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Grik1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HOMER2  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which Grik1 is involved
No pathways found





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