Gene description for Cxcl1
Gene name chemokine (C-X-C motif) ligand 1
Gene symbol Cxcl1
Other names/aliases Fsp
Gro1
KC
Mgsa
N51
Scyb1
gro
Species Mus musculus
 Database cross references - Cxcl1
ExoCarta ExoCarta_14825
Vesiclepedia VP_14825
Entrez Gene 14825
UniProt P12850  
 Cxcl1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Cxcl1
Molecular Function
    chemokine activity GO:0008009 IEA
    chemokine activity GO:0008009 ISO
    growth factor activity GO:0008083 IEA
Biological Process
    inflammatory response GO:0006954 IEA
    immune response GO:0006955 IEA
    signal transduction GO:0007165 IEA
    positive regulation of cytosolic calcium ion concentration GO:0007204 ISO
    positive regulation of sodium ion transport GO:0010765 ISO
    neutrophil chemotaxis GO:0030593 ISO
    positive regulation of superoxide anion generation GO:0032930 IDA
    positive regulation of potassium ion transport GO:0043268 ISO
    cell chemotaxis GO:0060326 IEA
    positive regulation of neutrophil mediated killing of fungus GO:0070965 IDA
    cellular response to interleukin-17 GO:0097398 IDA
    positive regulation of hematopoietic stem cell proliferation GO:1902035 IDA
Subcellular Localization
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 IDA
    extracellular space GO:0005615 ISO
 Experiment description of studies that identified Cxcl1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Cxcl1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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