Gene description for Cxcl1
Gene name chemokine (C-X-C motif) ligand 1
Gene symbol Cxcl1
Other names/aliases Fsp
Gro1
KC
Mgsa
N51
Scyb1
gro
Species Mus musculus
 Database cross references - Cxcl1
ExoCarta ExoCarta_14825
Entrez Gene 14825
UniProt P12850  
 Cxcl1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Cxcl1
Molecular Function
    growth factor activity GO:0008083 IEA
    cytokine activity GO:0005125 IEA
    chemokine activity GO:0008009 ISO
    CXCR chemokine receptor binding GO:0045236 IBA
Biological Process
    positive regulation of hematopoietic stem cell proliferation GO:1902035 IDA
    response to molecule of bacterial origin GO:0002237 ISO
    acute inflammatory response GO:0002526 ISO
    cell chemotaxis GO:0060326 IBA
    positive regulation of neutrophil mediated killing of fungus GO:0070965 IDA
    chemokine-mediated signaling pathway GO:0070098 IBA
    positive regulation of leukocyte chemotaxis GO:0002690 IBA
    neutrophil chemotaxis GO:0030593 ISO
    positive regulation of potassium ion transport GO:0043268 ISO
    response to lipopolysaccharide GO:0032496 IBA
    positive regulation of cytosolic calcium ion concentration GO:0007204 ISO
    immune response GO:0006955 IBA
    G-protein coupled receptor signaling pathway GO:0007186 IBA
    inflammatory response GO:0006954 IBA
    positive regulation of superoxide anion generation GO:0032930 IDA
    positive regulation of sodium ion transport GO:0010765 ISO
Subcellular Localization
    cell GO:0005623 ISO
    extracellular region GO:0005576 IEA
    cytosol GO:0005829 ISO
    extracellular space GO:0005615 ISO
 Experiment description of studies that identified Cxcl1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Cxcl1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cxcl1 is involved
PathwayEvidenceSource
Chemokine receptors bind chemokines IEA Reactome
G alpha (i) signalling events IEA Reactome





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