Gene description for H2-Ab1
Gene name histocompatibility 2, class II antigen A, beta 1
Gene symbol H2-Ab1
Other names/aliases AI845868
Abeta
H-2Ab
H2-Ab
I-Abeta
IAb
Ia-2
Ia2
Rmcs1
Species Mus musculus
 Database cross references - H2-Ab1
ExoCarta ExoCarta_14961
Entrez Gene 14961
UniProt P14483  
 H2-Ab1 identified in exosomes derived from the following tissue/cell type
Dendritic cells 10545503    
 Gene ontology annotations for H2-Ab1
Molecular Function
    repressing transcription factor binding GO:0070491 IPI
    transcription factor binding GO:0008134 IDA
    toxic substance binding GO:0015643 IPI
    peptide antigen binding GO:0042605 IDA
    protein heterodimerization activity GO:0046982 ISO
    ubiquitin protein ligase binding GO:0031625 IPI
    protein binding GO:0005515 IPI
Biological Process
    B cell affinity maturation GO:0002344 IDA
    antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 IEA
    antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 IDA
    antigen processing and presentation GO:0019882 IDA
    positive regulation of alpha-beta T cell activation GO:0046635 TAS
    antigen processing and presentation of peptide antigen GO:0048002 IDA
    positive regulation of antigen processing and presentation GO:0002579 IDA
    immune system process GO:0002376 IEA
    humoral immune response mediated by circulating immunoglobulin GO:0002455 ISO
    negative regulation of T cell proliferation GO:0042130 ISO
    immune response GO:0006955 IMP
    positive regulation of T-helper 1 type immune response GO:0002827 IDA
    cellular response to interferon-gamma GO:0071346 IDA
    immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 ISO
Subcellular Localization
    multivesicular body GO:0005771 IDA
    external side of plasma membrane GO:0009897 IDA
    cell surface GO:0009986 ISO
    MHC class II protein complex GO:0042613 IDA
    intracellular GO:0005622 IDA
    membrane GO:0016020 ISO
    integral component of membrane GO:0016021 IDA
    Golgi apparatus GO:0005794 IDA
    early endosome GO:0005769 IDA
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified H2-Ab1 in exosomes
1
Experiment ID 3
ISEV standards
IEM
EV Biophysical techniques
HSP84|HSC73
EV Cytosolic markers
MHCII|CD9|mac-1
EV Membrane markers
CANX|HSP90B1
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
Western blotting
PubMed ID 10545503    
Organism Mus musculus
Experiment description Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73.
Authors Thery C, Regnault A, Garin J, Wolfers J, Zitvogel L, Ricciardi-Castagnoli P, Raposo G, Amigorena S.
Journal name JCB
Publication year 1999
Sample Dendritic cells
Sample name D1
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
 Protein-protein interactions for H2-Ab1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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