Gene description for H2-K1
Gene name histocompatibility 2, K1, K region
Gene symbol H2-K1
Other names/aliases H-2K
H-2K(d)
H2-K
K-f
Species Mus musculus
 Database cross references - H2-K1
ExoCarta ExoCarta_14972
Entrez Gene 14972
UniProt P01901  
 H2-K1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for H2-K1
Molecular Function
    beta-2-microglobulin binding GO:0030881 ISO
    receptor binding GO:0005102 ISO
    poly(A) RNA binding GO:0044822 ISO
    TAP binding GO:0046977 ISO
    protein binding GO:0005515 IPI
    T cell receptor binding GO:0042608 ISO
    protein heterodimerization activity GO:0046982 ISO
    peptide binding GO:0042277 ISO
    peptide antigen binding GO:0042605 ISO
Biological Process
    immune system process GO:0002376 IEA
    positive regulation of T cell mediated cytotoxicity GO:0001916 IDA
    immune response GO:0006955 IEA
    defense response to bacterium GO:0042742 IDA
    inner ear development GO:0048839 IDA
    antigen processing and presentation GO:0019882 IEA
    antigen processing and presentation of peptide antigen via MHC class I GO:0002474 IEA
    antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent GO:0002485 IDA
    antigen processing and presentation of exogenous peptide antigen via MHC class I GO:0042590 IDA
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    Golgi medial cisterna GO:0005797 ISO
    Golgi apparatus GO:0005794 ISO
    endoplasmic reticulum exit site GO:0070971 ISO
    membrane GO:0016020 ISO
    external side of plasma membrane GO:0009897 IDA
    cell surface GO:0009986 ISO
    integral component of membrane GO:0016021 IEA
    endoplasmic reticulum GO:0005783 ISO
    plasma membrane GO:0005886 IBA
    MHC class I protein complex GO:0042612 ISO
 Experiment description of studies that identified H2-K1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for H2-K1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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