Gene description for H2-L
Gene name histocompatibility 2, D region locus L
Gene symbol H2-L
Other names/aliases H-2L
Species Mus musculus
 Database cross references - H2-L
ExoCarta ExoCarta_14980
Entrez Gene 14980
 H2-L identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for H2-L
Molecular Function
    peptide antigen binding GO:0042605 IEA
Biological Process
    antigen processing and presentation GO:0019882 IEA
    antigen processing and presentation of peptide antigen via MHC class I GO:0002474 IEA
    immune system process GO:0002376 IEA
    defense response GO:0006952 TAS
    immune response GO:0006955 IEA
Subcellular Localization
    MHC class I protein complex GO:0042612 IEA
    membrane GO:0016020 IEA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified H2-L in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for H2-L
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which H2-L is involved
No pathways found





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