Gene description for H2-M3
Gene name histocompatibility 2, M region locus 3
Gene symbol H2-M3
Other names/aliases H-2M3
Hmt
M3a
R4B2
Species Mus musculus
 Database cross references - H2-M3
ExoCarta ExoCarta_14991
Entrez Gene 14991
 H2-M3 identified in exosomes derived from the following tissue/cell type
Mammary adenocarcinoma cells 11231627    
 Gene ontology annotations for H2-M3
Molecular Function
    receptor binding GO:0005102 ISO
    protein homodimerization activity GO:0042803 ISO
    peptide antigen binding GO:0042605 IMP
Biological Process
    antigen processing and presentation of peptide antigen via MHC class I GO:0002474 IBA
    positive regulation of T cell tolerance induction GO:0002666 ISO
    antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 IDA
    antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent GO:0002481 IDA
    defense response to bacterium GO:0042742 IMP
    alpha-beta T cell activation involved in immune response GO:0002287 IMP
    immune response-inhibiting cell surface receptor signaling pathway GO:0002767 ISO
    negative regulation of dendritic cell differentiation GO:2001199 ISO
    response to molecule of bacterial origin GO:0002237 IDA
    antigen processing and presentation of exogenous peptide antigen via MHC class Ib GO:0002477 IDA
    positive regulation of interferon-gamma production GO:0032729 IMP
    negative regulation of T cell proliferation GO:0042130 ISO
    positive regulation of regulatory T cell differentiation GO:0045591 ISO
    positive regulation of tolerance induction GO:0002645 ISO
    positive regulation of interleukin-12 production GO:0032735 ISO
    positive regulation of natural killer cell mediated cytotoxicity GO:0045954 IMP
    positive regulation of T cell mediated cytotoxicity GO:0001916 IMP
    positive regulation of nitric oxide biosynthetic process GO:0045429 IMP
Subcellular Localization
    plasma membrane GO:0005886 IBA
    external side of plasma membrane GO:0009897 IDA
    membrane GO:0016020 ISO
    MHC class Ib protein complex GO:0032398 IDA
 Experiment description of studies that identified H2-M3 in exosomes
1
Experiment ID 23
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 11231627    
Organism Mus musculus
Experiment description Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming.
Authors Wolfers J, Lozier A, Raposo G, Regnault A, Thery C, Masurier C, Flament C, Pouzieux S, Faure F, Tursz T, Angevin E, Amigorena S, Zitvogel L
Journal name NM
Publication year 2001
Sample Mammary adenocarcinoma cells
Sample name TS/A (H-2d)
P815 mastocytoma cells (H-2d)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for H2-M3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which H2-M3 is involved
No pathways found





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