Gene description for H2-M3
Gene name histocompatibility 2, M region locus 3
Gene symbol H2-M3
Other names/aliases H-2M3
Hmt
M3a
R4B2
Species Mus musculus
 Database cross references - H2-M3
ExoCarta ExoCarta_14991
Vesiclepedia VP_14991
Entrez Gene 14991
 H2-M3 identified in sEVs derived from the following tissue/cell type
Mammary adenocarcinoma cells 11231627    
 Gene ontology annotations for H2-M3
Molecular Function
    signaling receptor binding GO:0005102 IBA
    signaling receptor binding GO:0005102 ISO
    peptide antigen binding GO:0042605 IBA
    peptide antigen binding GO:0042605 IDA
    peptide antigen binding GO:0042605 IMP
    peptide antigen binding GO:0042605 ISO
    CD8 receptor binding GO:0042610 ISO
    identical protein binding GO:0042802 ISO
    protein homodimerization activity GO:0042803 ISO
Biological Process
    negative regulation of T cell mediated cytotoxicity GO:0001915 ISO
    positive regulation of T cell mediated cytotoxicity GO:0001916 IBA
    positive regulation of T cell mediated cytotoxicity GO:0001916 IDA
    positive regulation of T cell mediated cytotoxicity GO:0001916 IMP
    response to molecule of bacterial origin GO:0002237 IDA
    alpha-beta T cell activation involved in immune response GO:0002287 IMP
    peripheral B cell tolerance induction GO:0002451 ISO
    antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 IBA
    antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 IDA
    antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 ISO
    antigen processing and presentation of exogenous peptide antigen via MHC class Ib GO:0002477 IDA
    antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent GO:0002481 IDA
    antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent GO:0002486 IBA
    positive regulation of tolerance induction GO:0002645 ISO
    positive regulation of T cell tolerance induction GO:0002666 ISO
    positive regulation of natural killer cell cytokine production GO:0002729 ISO
    immune response-inhibiting cell surface receptor signaling pathway GO:0002767 ISO
    nitric oxide biosynthetic process GO:0006809 IMP
    immune response GO:0006955 IBA
    negative regulation of angiogenesis GO:0016525 ISO
    positive regulation of type II interferon production GO:0032729 IMP
    positive regulation of interleukin-12 production GO:0032735 ISO
    negative regulation of T cell proliferation GO:0042130 ISO
    protection from natural killer cell mediated cytotoxicity GO:0042270 ISO
    defense response to bacterium GO:0042742 IDA
    defense response to bacterium GO:0042742 IMP
    positive regulation of nitric oxide biosynthetic process GO:0045429 IMP
    positive regulation of regulatory T cell differentiation GO:0045591 ISO
    negative regulation of natural killer cell mediated cytotoxicity GO:0045953 ISO
    positive regulation of natural killer cell mediated cytotoxicity GO:0045954 IMP
    negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051898 ISO
    positive regulation of macrophage cytokine production GO:0060907 ISO
    protein homotrimerization GO:0070207 ISO
    negative regulation of G0 to G1 transition GO:0070317 ISO
    positive regulation of endothelial cell apoptotic process GO:2000353 ISO
    positive regulation of cellular senescence GO:2000774 ISO
    negative regulation of dendritic cell differentiation GO:2001199 ISO
Subcellular Localization
    extracellular space GO:0005615 IBA
    early endosome GO:0005769 ISO
    plasma membrane GO:0005886 ISO
    external side of plasma membrane GO:0009897 IBA
    external side of plasma membrane GO:0009897 IDA
    MHC class Ib protein complex GO:0032398 IDA
    cis-Golgi network membrane GO:0033106 ISO
 Experiment description of studies that identified H2-M3 in sEVs
1
Experiment ID 23
MISEV standards
EM
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 11231627    
Organism Mus musculus
Experiment description Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming.
Authors "Wolfers J, Lozier A, Raposo G, Regnault A, Thery C, Masurier C, Flament C, Pouzieux S, Faure F, Tursz T, Angevin E, Amigorena S, Zitvogel L"
Journal name NM
Publication year 2001
Sample Mammary adenocarcinoma cells
Sample name TS/A (H-2d)
P815 mastocytoma cells (H-2d)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for H2-M3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which H2-M3 is involved
No pathways found





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