Gene description for Hbb-b2
Gene name hemoglobin, beta adult minor chain
Gene symbol Hbb-b2
Other names/aliases AI036344
Hbb2
Hbbt2
beta2
Species Mus musculus
 Database cross references - Hbb-b2
ExoCarta ExoCarta_15130
Entrez Gene 15130
UniProt P02089  
 Hbb-b2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Hbb-b2
Molecular Function
    oxygen transporter activity GO:0005344 IEA
    oxygen binding GO:0019825 IMP
    metal ion binding GO:0046872 IEA
    iron ion binding GO:0005506 IEA
    heme binding GO:0020037 IEA
Biological Process
    positive regulation of myeloid cell differentiation GO:0045639 IMP
    erythrocyte development GO:0048821 IGI
    oxygen transport GO:0015671 IEA
    transport GO:0006810 IEA
    regulation of erythrocyte differentiation GO:0045646 IMP
Subcellular Localization
    hemoglobin complex GO:0005833 IMP
 Experiment description of studies that identified Hbb-b2 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Hbb-b2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Hbb-b2 is involved
No pathways found





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