Gene description for Mst1
Gene name macrophage stimulating 1 (hepatocyte growth factor-like)
Gene symbol Mst1
Other names/aliases D3F15S2h
D9H3F15S2
DNF15S2h
Hgfl
Species Mus musculus
 Database cross references - Mst1
ExoCarta ExoCarta_15235
Vesiclepedia VP_15235
Entrez Gene 15235
UniProt P26928  
 Mst1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Mst1
Molecular Function
    endopeptidase activity GO:0004175 IBA
    serine-type endopeptidase activity GO:0004252 IEA
    enzyme binding GO:0019899 ISO
    receptor tyrosine kinase binding GO:0030971 IBA
    receptor tyrosine kinase binding GO:0030971 ISO
    receptor tyrosine kinase binding GO:0030971 ISS
    histone kinase activity GO:0035173 IEA
    histone kinase activity GO:0035173 ISO
Biological Process
    chromatin remodeling GO:0006338 IEA
    proteolysis GO:0006508 IEA
    spermatogenesis GO:0007283 IEA
    embryo implantation GO:0007566 IDA
    positive regulation of gene expression GO:0010628 IMP
    regulation of macrophage chemotaxis GO:0010758 IMP
    flagellated sperm motility GO:0030317 IEA
    mammary gland development GO:0030879 IMP
    positive regulation of mammary gland epithelial cell proliferation GO:0033601 IMP
    protein modification process GO:0036211 IEA
    protein modification process GO:0036211 ISO
    positive regulation of apoptotic process GO:0043065 IEA
    positive regulation of apoptotic process GO:0043065 ISO
    negative regulation of gluconeogenesis GO:0045721 ISS
    regulation of receptor signaling pathway via JAK-STAT GO:0046425 IBA
    regulation of receptor signaling pathway via JAK-STAT GO:0046425 IMP
    mammary duct terminal end bud growth GO:0060763 IMP
    cellular response to type II interferon GO:0071346 IEA
    cellular response to hypoxia GO:0071456 IEA
    negative regulation of epithelial cell apoptotic process GO:1904036 IMP
    regulation of cAMP-dependent protein kinase activity GO:2000479 ISS
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 ISO
    extracellular space GO:0005615 ISS
    vacuole GO:0005773 IDA
 Experiment description of studies that identified Mst1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Mst1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Mst1 is involved
PathwayEvidenceSource
Signal Transduction IEA Reactome
Signaling by MST1 IEA Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome





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