Gene description for Hipk3
Gene name homeodomain interacting protein kinase 3
Gene symbol Hipk3
Other names/aliases DYRK6
FIST3
PKY
mir-1902
Species Mus musculus
 Database cross references - Hipk3
ExoCarta ExoCarta_15259
Entrez Gene 15259
UniProt Q9ERH7  
 Hipk3 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Hipk3
Molecular Function
    DNA binding GO:0003677 ISS
    protein serine/threonine kinase activity GO:0004674 IDA
    transcription corepressor activity GO:0003714 ISS
    nucleotide binding GO:0000166 IEA
    protein kinase activity GO:0004672 ISS
    transferase activity, transferring phosphorus-containing groups GO:0016772 IEA
    protein binding GO:0005515 IPI
    transferase activity GO:0016740 IEA
    kinase activity GO:0016301 IEA
    ATP binding GO:0005524 IEA
Biological Process
    negative regulation of apoptotic process GO:0043066 ISO
    peptidyl-serine phosphorylation GO:0018105 IDA
    mRNA transcription GO:0009299 ISO
    negative regulation of JUN kinase activity GO:0043508 IMP
    regulation of transcription, DNA-templated GO:0006355 IEA
    protein phosphorylation GO:0006468 ISS
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISS
    phosphorylation GO:0016310 IEA
    positive regulation of DNA binding GO:0043388 ISS
    peptidyl-threonine phosphorylation GO:0018107 IDA
    apoptotic process GO:0006915 IEA
    transcription, DNA-templated GO:0006351 IEA
Subcellular Localization
    PML body GO:0016605 IDA
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Hipk3 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Hipk3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Hipk3 is involved
No pathways found





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