Gene description for Hmgn1
Gene name high mobility group nucleosomal binding domain 1
Gene symbol Hmgn1
Other names/aliases HMG-14
Hmg14
Species Mus musculus
 Database cross references - Hmgn1
ExoCarta ExoCarta_15312
Entrez Gene 15312
UniProt P18608  
 Hmgn1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Hmgn1
Molecular Function
    DNA binding GO:0003677 IEA
    nucleosomal DNA binding GO:0031492 IEA
    chromatin binding GO:0003682 IDA
Biological Process
    transcription-coupled nucleotide-excision repair GO:0006283 IMP
    regulation of transcription from RNA polymerase II promoter GO:0006357 IMP
    post-embryonic camera-type eye morphogenesis GO:0048597 IMP
    regulation of development, heterochronic GO:0040034 IGI
    pyrimidine dimer repair by nucleotide-excision repair GO:0000720 IMP
    chromatin organization GO:0006325 IMP
    regulation of epithelial cell proliferation GO:0050678 IMP
    response to UV-C GO:0010225 IDA
    response to UV-B GO:0010224 IMP
Subcellular Localization
    nucleus GO:0005634 ISO
    chromatin GO:0000785 IEA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified Hmgn1 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Hmgn1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Hmgn1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here