Gene description for Hmox1
Gene name	heme oxygenase 1
Gene symbol	Hmox1
Other names/aliases	D8Wsu38e HO-1 HO1 Hemox Hmox Hsp32
Species	Mus musculus
Database cross references - Hmox1
ExoCarta	ExoCarta_15368
Vesiclepedia	VP_15368
Entrez Gene	15368
UniProt	P14901
Hmox1 identified in sEVs derived from the following tissue/cell type
Pancreatic cells	19351151

Gene ontology annotations for Hmox1

Molecular Function     heme oxygenase (decyclizing) activity GO:0004392 IBA     heme oxygenase (decyclizing) activity GO:0004392 ISO     heme oxygenase (decyclizing) activity GO:0004392 ISS     phospholipase D activity GO:0004630 ISO     structural molecule activity GO:0005198 IEA     structural molecule activity GO:0005198 ISO     protein binding GO:0005515 IPI     enzyme binding GO:0019899 ISO     heme binding GO:0020037 IBA     heme binding GO:0020037 IEA     heme binding GO:0020037 ISO     identical protein binding GO:0042802 ISO     protein homodimerization activity GO:0042803 IEA     protein homodimerization activity GO:0042803 ISO     metal ion binding GO:0046872 IEA     arachidonate omega-hydroxylase activity GO:0052869 ISO Biological Process     angiogenesis GO:0001525 ISO     response to hypoxia GO:0001666 ISO     wound healing involved in inflammatory response GO:0002246 IEA     wound healing involved in inflammatory response GO:0002246 ISO     regulation of transcription by RNA polymerase II GO:0006357 ISO     heme oxidation GO:0006788 IBA     heme oxidation GO:0006788 IEA     heme oxidation GO:0006788 ISO     intracellular iron ion homeostasis GO:0006879 IEA     intracellular iron ion homeostasis GO:0006879 ISO     response to oxidative stress GO:0006979 IBA     response to oxidative stress GO:0006979 IEA     response to oxidative stress GO:0006979 ISO     small GTPase-mediated signal transduction GO:0007264 ISO     regulation of blood pressure GO:0008217 ISO     negative regulation of cell population proliferation GO:0008285 ISO     intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 ISO     negative regulation of muscle cell apoptotic process GO:0010656 ISO     macroautophagy GO:0016236 IMP     positive regulation of macroautophagy GO:0016239 IMP     negative regulation of macroautophagy GO:0016242 IMP     negative regulation of mast cell cytokine production GO:0032764 ISO     erythrocyte homeostasis GO:0034101 IEA     erythrocyte homeostasis GO:0034101 ISO     cellular response to heat GO:0034605 IEA     cellular response to heat GO:0034605 ISO     response to nicotine GO:0035094 IEA     response to nicotine GO:0035094 ISO     intracellular signal transduction GO:0035556 ISO     heme catabolic process GO:0042167 IBA     heme catabolic process GO:0042167 IGI     heme catabolic process GO:0042167 ISO     heme metabolic process GO:0042168 IDA     response to hydrogen peroxide GO:0042542 ISO     negative regulation of mast cell degranulation GO:0043305 ISO     negative regulation of neuron apoptotic process GO:0043524 ISO     response to estrogen GO:0043627 ISO     positive regulation of angiogenesis GO:0045766 IEA     positive regulation of angiogenesis GO:0045766 ISO     positive regulation of smooth muscle cell proliferation GO:0048661 IEA     positive regulation of smooth muscle cell proliferation GO:0048661 ISO     negative regulation of smooth muscle cell proliferation GO:0048662 IEA     negative regulation of smooth muscle cell proliferation GO:0048662 ISO     multicellular organismal-level iron ion homeostasis GO:0060586 IEA     multicellular organismal-level iron ion homeostasis GO:0060586 ISO     cellular response to arsenic-containing substance GO:0071243 IDA     cellular response to cadmium ion GO:0071276 IDA     cellular response to cisplatin GO:0072719 IMP     positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 IEA     positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 ISO     liver regeneration GO:0097421 ISO     negative regulation of ferroptosis GO:0110076 ISO     negative regulation of ferroptosis GO:0110076 ISS     negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 IEA     negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 ISO     positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903589 IEA     positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903589 ISO     epithelial cell apoptotic process GO:1904019 IMP     negative regulation of epithelial cell apoptotic process GO:1904036 ISO     positive regulation of epithelial cell apoptotic process GO:1904037 IMP     response to arachidonate GO:1904550 ISO     negative regulation of vascular associated smooth muscle cell proliferation GO:1904706 ISO Subcellular Localization     nucleus GO:0005634 IDA     nucleus GO:0005634 ISO     endoplasmic reticulum GO:0005783 ISO     endoplasmic reticulum membrane GO:0005789 ISO     endoplasmic reticulum membrane GO:0005789 ISS     cytosol GO:0005829 IGI     caveola GO:0005901 ISO     perinuclear region of cytoplasm GO:0048471 IEA     perinuclear region of cytoplasm GO:0048471 ISO