Gene description for Icam1
Gene name	intercellular adhesion molecule 1
Gene symbol	Icam1
Other names/aliases	CD54 Icam-1 Ly-47 MALA-2
Species	Mus musculus
Database cross references - Icam1
ExoCarta	ExoCarta_15894
Vesiclepedia	VP_15894
Entrez Gene	15894
UniProt	P13597
Icam1 identified in sEVs derived from the following tissue/cell type
Macrophages	23658846
Macrophages	23658846
Macrophages	23658846
Mast cells	11145662
Mast cells	11306949
Mast cells	17486113
Melanoma cells	34957415
Melanoma cells	34957415

Gene ontology annotations for Icam1

Molecular Function     integrin binding GO:0005178 IBA     integrin binding GO:0005178 ISO     protein-containing complex binding GO:0044877 ISO Biological Process     T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:0002291 IEA     T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:0002291 ISO     acute inflammatory response to antigenic stimulus GO:0002438 ISO     T cell antigen processing and presentation GO:0002457 IDA     positive regulation of cellular extravasation GO:0002693 IEA     positive regulation of cellular extravasation GO:0002693 ISO     cell adhesion GO:0007155 IBA     cell adhesion GO:0007155 IDA     cell adhesion GO:0007155 ISO     leukocyte cell-cell adhesion GO:0007159 IMP     leukocyte cell-cell adhesion GO:0007159 ISO     regulation of cell shape GO:0008360 ISO     membrane to membrane docking GO:0022614 IEA     positive regulation of actin filament polymerization GO:0030838 ISO     cell adhesion mediated by integrin GO:0033627 IDA     adhesion of symbiont to host GO:0044406 ISO     positive regulation of nitric oxide biosynthetic process GO:0045429 ISO     positive regulation of vasoconstriction GO:0045907 ISO     receptor-mediated virion attachment to host cell GO:0046813 IEA     receptor-mediated virion attachment to host cell GO:0046813 ISO     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO     negative regulation of calcium ion transport GO:0051926 ISO     establishment of endothelial barrier GO:0061028 IEA     establishment of endothelial barrier GO:0061028 ISO     positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO     cellular response to glucose stimulus GO:0071333 IDA     T cell extravasation GO:0072683 IMP     establishment of endothelial intestinal barrier GO:0090557 ISO     establishment of Sertoli cell barrier GO:0097368 ISO     cell-cell adhesion GO:0098609 ISO     regulation of ruffle assembly GO:1900027 IDA     negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 IEA     negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 ISO     cellular response to amyloid-beta GO:1904646 IEA     cellular response to amyloid-beta GO:1904646 ISO     positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 ISO     cellular response to leukemia inhibitory factor GO:1990830 IEP     negative regulation of endothelial cell apoptotic process GO:2000352 IEA     negative regulation of endothelial cell apoptotic process GO:2000352 ISO Subcellular Localization     immunological synapse GO:0001772 IDA     extracellular space GO:0005615 ISO     plasma membrane GO:0005886 IBA     external side of plasma membrane GO:0009897 IDA     cell surface GO:0009986 ISO     membrane raft GO:0045121 IDA     extracellular exosome GO:0070062 IEA     extracellular exosome GO:0070062 ISO