Gene description for Igf2r
Gene name insulin-like growth factor 2 receptor
Gene symbol Igf2r
Other names/aliases AI661837
Species Mus musculus
 Database cross references - Igf2r
ExoCarta ExoCarta_16004
Entrez Gene 16004
UniProt Q07113  
 Igf2r identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Igf2r
Molecular Function
    insulin-like growth factor II binding GO:0031995 ISO
    phosphoprotein binding GO:0051219 ISO
    G-protein coupled receptor activity GO:0004930 ISO
    enzyme binding GO:0019899 ISO
    retinoic acid binding GO:0001972 ISO
    mannose binding GO:0005537 IDA
    insulin-like growth factor binding GO:0005520 IPI
    glycoprotein binding GO:0001948 ISO
    transporter activity GO:0005215 IEA
    G-protein alpha-subunit binding GO:0001965 ISO
    identical protein binding GO:0042802 ISO
Biological Process
    liver development GO:0001889 ISO
    positive regulation of apoptotic process GO:0043065 ISO
    transport GO:0006810 IEA
    regulation of apoptotic process GO:0042981 ISO
    G-protein coupled receptor signaling pathway GO:0007186 ISO
    response to retinoic acid GO:0032526 ISO
Subcellular Localization
    endocytic vesicle GO:0030139 ISO
    trans-Golgi network transport vesicle GO:0030140 ISO
    extracellular exosome GO:0070062 ISO
    trans-Golgi network GO:0005802 ISO
    nucleus GO:0005634 IDA
    lysosome GO:0005764 IEA
    late endosome GO:0005770 ISO
    nuclear envelope lumen GO:0005641 IDA
    endosome GO:0005768 ISO
    membrane GO:0016020 ISO
    extracellular space GO:0005615 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    early endosome GO:0005769 ISO
    cytoplasm GO:0005737 IEA
    clathrin coat GO:0030118 ISO
    plasma membrane GO:0005886 ISO
    integral component of membrane GO:0016021 IEA
    cell surface GO:0009986 ISO
    focal adhesion GO:0005925 ISO
 Experiment description of studies that identified Igf2r in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Igf2r
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Igf2r is involved
Golgi Associated Vesicle Biogenesis IEA Reactome

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