Gene description for MDGA2
Gene name MAM domain containing glycosylphosphatidylinositol anchor 2
Gene symbol MDGA2
Other names/aliases MAMDC1
c14_5286
Species Homo sapiens
 Database cross references - MDGA2
ExoCarta ExoCarta_161357
Entrez Gene 161357
HGNC 19835
MIM 611128
UniProt Q7Z553  
 MDGA2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for MDGA2
Biological Process
    pattern specification process GO:0007389 IEA
    spinal cord motor neuron differentiation GO:0021522 ISS
Subcellular Localization
    plasma membrane GO:0005886 IEA
    anchored component of membrane GO:0031225 IEA
 Experiment description of studies that identified MDGA2 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for MDGA2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MDGA2 is involved
No pathways found





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