Gene description for Psmd9
Gene name proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
Gene symbol Psmd9
Other names/aliases Bridge
Bridge-1
Species Rattus norvegicus
 Database cross references - Psmd9
ExoCarta ExoCarta_161475
Vesiclepedia VP_161475
Entrez Gene 161475
UniProt Q9WTV5  
 Psmd9 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Psmd9
Molecular Function
    transcription coactivator activity GO:0003713 IDA
    protein binding GO:0005515 IPI
    bHLH transcription factor binding GO:0043425 IDA
    bHLH transcription factor binding GO:0043425 IPI
Biological Process
    positive regulation of insulin secretion GO:0032024 IDA
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    negative regulation of insulin secretion GO:0046676 IMP
    proteasome regulatory particle assembly GO:0070682 IBA
    proteasome regulatory particle assembly GO:0070682 ISO
    proteasome regulatory particle assembly GO:0070682 ISS
    type B pancreatic cell apoptotic process GO:0097050 IMP
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IBA
    proteasome regulatory particle, base subcomplex GO:0008540 ISO
 Experiment description of studies that identified Psmd9 in sEVs
1
Experiment ID 98
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Psmd9
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ep300  
Affinity Capture-Western Rattus norvegicus
2 Tcf3  
Two-hybrid Rattus norvegicus
Reconstituted Complex Rattus norvegicus
View the network image/svg+xml
 Pathways in which Psmd9 is involved
PathwayEvidenceSource
Metabolism of proteins IEA Reactome
Post-translational protein modification IEA Reactome
Proteasome assembly IEA Reactome





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