Gene description for Cd74
Gene name	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
Gene symbol	Cd74
Other names/aliases	CLIP DHLAG HLADG Ia-GAMMA Ii
Species	Mus musculus
Database cross references - Cd74
ExoCarta	ExoCarta_16149
Vesiclepedia	VP_16149
Entrez Gene	16149
UniProt	P04441
Cd74 identified in sEVs derived from the following tissue/cell type
Microglia	16081791

Gene ontology annotations for Cd74

Molecular Function     amyloid-beta binding GO:0001540 IEA     amyloid-beta binding GO:0001540 ISO     cytokine receptor activity GO:0004896 IBA     cytokine receptor activity GO:0004896 IMP     cytokine receptor activity GO:0004896 ISO     protein binding GO:0005515 IPI     cytokine binding GO:0019955 IDA     cytokine binding GO:0019955 ISO     MHC class II protein complex binding GO:0023026 ISO     macrophage migration inhibitory factor binding GO:0035718 IBA     macrophage migration inhibitory factor binding GO:0035718 IEA     macrophage migration inhibitory factor binding GO:0035718 ISO     MHC class II protein binding GO:0042289 IBA     MHC class II protein binding GO:0042289 IPI     CD4 receptor binding GO:0042609 IEA     CD4 receptor binding GO:0042609 ISO     MHC class II protein binding, via antigen binding groove GO:0042658 IEA     MHC class II protein binding, via antigen binding groove GO:0042658 ISO     protein folding chaperone GO:0044183 IEA     protein folding chaperone GO:0044183 ISO     nitric-oxide synthase binding GO:0050998 IPI Biological Process     prostaglandin biosynthetic process GO:0001516 ISO     prostaglandin biosynthetic process GO:0001516 ISS     positive regulation of protein phosphorylation GO:0001934 ISO     positive regulation of cytokine-mediated signaling pathway GO:0001961 IBA     positive regulation of cytokine-mediated signaling pathway GO:0001961 IMP     positive regulation of cytokine-mediated signaling pathway GO:0001961 ISO     T cell activation involved in immune response GO:0002286 IBA     positive regulation of dendritic cell antigen processing and presentation GO:0002606 IDA     negative regulation of peptide secretion GO:0002792 IEA     negative regulation of peptide secretion GO:0002792 ISO     positive regulation of adaptive immune response GO:0002821 NAS     positive regulation of type 2 immune response GO:0002830 IBA     positive regulation of type 2 immune response GO:0002830 IMP     negative regulation of mature B cell apoptotic process GO:0002906 IMP     intracellular protein transport GO:0006886 IDA     intracellular protein transport GO:0006886 IMP     defense response GO:0006952 IMP     positive regulation of gene expression GO:0010628 ISO     immunoglobulin mediated immune response GO:0016064 IMP     antigen processing and presentation GO:0019882 IBA     antigen processing and presentation GO:0019882 IDA     antigen processing and presentation GO:0019882 IMP     antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 IMP     negative regulation of cell migration GO:0030336 IEA     negative regulation of cell migration GO:0030336 ISO     positive regulation of B cell proliferation GO:0030890 IEA     positive regulation of B cell proliferation GO:0030890 ISO     positive regulation of prostaglandin biosynthetic process GO:0031394 IEA     positive regulation of prostaglandin biosynthetic process GO:0031394 ISO     positive regulation of chemokine production GO:0032722 ISO     positive regulation of interleukin-6 production GO:0032755 IEA     positive regulation of interleukin-6 production GO:0032755 ISO     positive regulation of interleukin-8 production GO:0032757 IEA     positive regulation of interleukin-8 production GO:0032757 ISO     positive regulation of kinase activity GO:0033674 ISO     response to type II interferon GO:0034341 IDA     response to type II interferon GO:0034341 ISO     macrophage migration inhibitory factor signaling pathway GO:0035691 IDA     negative regulation of apoptotic process GO:0043066 ISO     negative regulation of apoptotic process GO:0043066 ISS     positive regulation of canonical NF-kappaB signal transduction GO:0043123 IEA     positive regulation of canonical NF-kappaB signal transduction GO:0043123 ISO     positive regulation of MAPK cascade GO:0043410 ISO     negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 IBA     negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 IMP     negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 ISO     positive thymic T cell selection GO:0045059 IMP     negative thymic T cell selection GO:0045060 IMP     positive regulation of innate immune response GO:0045089 IC     negative regulation of T cell differentiation GO:0045581 IMP     positive regulation of T cell differentiation GO:0045582 IMP     positive regulation of monocyte differentiation GO:0045657 IEA     positive regulation of monocyte differentiation GO:0045657 ISO     positive regulation of DNA-templated transcription GO:0045893 IEA     positive regulation of DNA-templated transcription GO:0045893 ISO     negative regulation of viral entry into host cell GO:0046597 ISO     positive regulation of viral entry into host cell GO:0046598 IEA     positive regulation of viral entry into host cell GO:0046598 ISO     positive regulation of fibroblast proliferation GO:0048146 IEA     positive regulation of fibroblast proliferation GO:0048146 ISO     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO     protein stabilization GO:0050821 IMP     chaperone cofactor-dependent protein refolding GO:0051085 IDA     chaperone cofactor-dependent protein refolding GO:0051085 IMP     positive regulation of macrophage cytokine production GO:0060907 IBA     positive regulation of macrophage cytokine production GO:0060907 IDA     protein-containing complex assembly GO:0065003 IDA     protein trimerization GO:0070206 IEA     positive regulation of ERK1 and ERK2 cascade GO:0070374 IBA     positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO     positive regulation of neutrophil chemotaxis GO:0090023 IDA     negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 IBA     negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 IMP     negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 ISO     positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 IDA     positive regulation of macrophage migration inhibitory factor signaling pathway GO:2000448 IEA     positive regulation of macrophage migration inhibitory factor signaling pathway GO:2000448 ISO Subcellular Localization     extracellular region GO:0005576 IEA     extracellular space GO:0005615 IDA     nucleus GO:0005634 IEA     nucleus GO:0005634 ISO     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 ISO     lysosome GO:0005764 IDA     late endosome GO:0005770 IDA     multivesicular body GO:0005771 IDA     vacuole GO:0005773 ISO     endoplasmic reticulum GO:0005783 IDA     endoplasmic reticulum membrane GO:0005789 IEA     Golgi apparatus GO:0005794 IDA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 IMP     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 TAS     external side of plasma membrane GO:0009897 IDA     cell surface GO:0009986 IBA     cell surface GO:0009986 ISO     membrane GO:0016020 ISO     protein-containing complex GO:0032991 ISO     macrophage migration inhibitory factor receptor complex GO:0035692 IDA     macrophage migration inhibitory factor receptor complex GO:0035692 ISO     NOS2-CD74 complex GO:0035693 IDA     MHC class II protein complex GO:0042613 IDA