Gene description for Cd74
Gene name	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
Gene symbol	Cd74
Other names/aliases	CLIP DHLAG HLADG Ia-GAMMA Ii
Species	Mus musculus
Database cross references - Cd74
ExoCarta	ExoCarta_16149
Entrez Gene	16149
UniProt	P04441
Cd74 identified in exosomes derived from the following tissue/cell type
Microglia	16081791

Gene ontology annotations for Cd74

Molecular Function     macrophage migration inhibitory factor binding GO:0035718 ISO     protein binding involved in protein folding GO:0044183 ISO     nitric-oxide synthase binding GO:0050998 IPI     cytokine binding GO:0019955 ISO     cytokine receptor activity GO:0004896 ISO     protein binding GO:0005515 IPI     beta-amyloid binding GO:0001540 ISO     MHC class II protein complex binding GO:0023026 ISO     MHC class II protein binding, via antigen binding groove GO:0042658 ISO     MHC class II protein binding GO:0042289 IPI Biological Process     cell proliferation GO:0008283 ISO     positive regulation of type 2 immune response GO:0002830 IMP     immune system process GO:0002376 IEA     negative thymic T cell selection GO:0045060 IMP     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO     negative regulation of mature B cell apoptotic process GO:0002906 IMP     positive regulation of B cell proliferation GO:0030890 ISO     prostaglandin biosynthetic process GO:0001516 ISO     negative regulation of apoptotic process GO:0043066 ISO     positive regulation of T cell differentiation GO:0045582 IMP     defense response GO:0006952 IMP     positive regulation of macrophage cytokine production GO:0060907 IDA     negative regulation of T cell differentiation GO:0045581 IMP     signal transduction GO:0007165 ISO     positive regulation of cytokine-mediated signaling pathway GO:0001961 ISO     macrophage migration inhibitory factor signaling pathway GO:0035691 IDA     positive regulation of adaptive immune response GO:0002821 NAS     immune response GO:0006955 IEA     positive thymic T cell selection GO:0045059 IMP     negative regulation of peptide secretion GO:0002792 ISO     negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 ISO     protein complex assembly GO:0006461 IDA     negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 ISO     positive regulation of neutrophil chemotaxis GO:0090023 IDA     positive regulation of fibroblast proliferation GO:0048146 ISO     positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 IDA     activation of MAPK activity GO:0000187 ISO     antigen processing and presentation GO:0019882 IMP     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO     protein folding GO:0006457 ISO     antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 IMP     intracellular protein transport GO:0006886 IMP     chaperone mediated protein folding requiring cofactor GO:0051085 IMP     immunoglobulin mediated immune response GO:0016064 IMP     cytokine-mediated signaling pathway GO:0019221 IMP     positive regulation of dendritic cell antigen processing and presentation GO:0002606 IDA     positive regulation of innate immune response GO:0045089 IC Subcellular Localization     vacuole GO:0005773 ISO     macrophage migration inhibitory factor receptor complex GO:0035692 ISO     cell surface GO:0009986 ISO     integral component of membrane GO:0016021 ISO     endoplasmic reticulum GO:0005783 IDA     MHC class II protein complex GO:0042613 IDA     external side of plasma membrane GO:0009897 IDA     lysosome GO:0005764 IDA     intracellular GO:0005622 IMP     multivesicular body GO:0005771 IDA     plasma membrane GO:0005886 IMP     late endosome GO:0005770 IDA     Golgi apparatus GO:0005794 IDA     membrane GO:0016020 ISO     integral component of plasma membrane GO:0005887 TAS     NOS2-CD74 complex GO:0035693 IDA     extracellular exosome GO:0070062 ISO