Gene description for Itih2
Gene name inter-alpha trypsin inhibitor, heavy chain 2
Gene symbol Itih2
Other names/aliases AI747202
Intin2
Itih-2
Species Mus musculus
 Database cross references - Itih2
ExoCarta ExoCarta_16425
Entrez Gene 16425
UniProt Q61703  
 Itih2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Itih2
Molecular Function
    peptidase inhibitor activity GO:0030414 IEA
    serine-type endopeptidase inhibitor activity GO:0004867 IEA
Biological Process
    hyaluronan metabolic process GO:0030212 IEA
    negative regulation of peptidase activity GO:0010466 IEA
Subcellular Localization
    extracellular region GO:0005576 IEA
    blood microparticle GO:0072562 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Itih2 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Itih2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Itih2 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here