Gene description for DDC
Gene name dopa decarboxylase (aromatic L-amino acid decarboxylase)
Gene symbol DDC
Other names/aliases AADC
Species Homo sapiens
 Database cross references - DDC
ExoCarta ExoCarta_1644
Entrez Gene 1644
HGNC 2719
MIM 107930
UniProt P20711  
 DDC identified in exosomes derived from the following tissue/cell type
Urine 19056867    
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for DDC
Molecular Function
    aromatic-L-amino-acid decarboxylase activity GO:0004058 TAS
    amino acid binding GO:0016597 IEA
    enzyme binding GO:0019899 IPI
    pyridoxal phosphate binding GO:0030170 IEA
    protein binding GO:0005515 IPI
    L-dopa decarboxylase activity GO:0036468 IDA
    protein domain specific binding GO:0019904 IEA
Biological Process
    cellular response to alkaloid GO:0071312 IEA
    cellular nitrogen compound metabolic process GO:0034641 TAS
    cellular amino acid metabolic process GO:0006520 IEA
    indolalkylamine biosynthetic process GO:0046219 TAS
    dopamine biosynthetic process GO:0042416 IEA
    synaptic vesicle amine transport GO:0015842 IEA
    isoquinoline alkaloid metabolic process GO:0033076 IEA
    multicellular organismal aging GO:0010259 IEA
    response to pyrethroid GO:0046684 IEA
    circadian rhythm GO:0007623 IEA
    serotonin biosynthetic process GO:0042427 IEA
    phytoalexin metabolic process GO:0052314 IEA
    cellular response to drug GO:0035690 IEA
    small molecule metabolic process GO:0044281 TAS
    cellular response to growth factor stimulus GO:0071363 IEA
    catecholamine biosynthetic process GO:0042423 TAS
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    axon GO:0030424 IEA
    cytosol GO:0005829 TAS
    synaptic vesicle GO:0008021 IEA
    neuronal cell body GO:0043025 IEA
 Experiment description of studies that identified DDC in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
2
Experiment ID 196
ISEV standards
EM
EV Biophysical techniques
Alix|TSG101|HSP70
EV Cytosolic markers
CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 197
ISEV standards
EM
EV Biophysical techniques
Alix|TSG101|HSP70
EV Cytosolic markers
CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for DDC
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NR3C1 2908
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which DDC is involved
PathwayEvidenceSource
Catecholamine biosynthesis TAS Reactome
Serotonin and melatonin biosynthesis TAS Reactome





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