Gene description for Kcnj11
Gene name potassium inwardly rectifying channel, subfamily J, member 11
Gene symbol Kcnj11
Other names/aliases Kir6.2
Species Mus musculus
 Database cross references - Kcnj11
ExoCarta ExoCarta_16514
Entrez Gene 16514
UniProt Q61743  
 Kcnj11 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Kcnj11
Molecular Function
    protein C-terminus binding GO:0008022 ISO
    ankyrin binding GO:0030506 ISO
    voltage-gated potassium channel activity GO:0005249 ISO
    heat shock protein binding GO:0031072 ISO
    voltage-gated ion channel activity GO:0005244 IEA
    ATP binding GO:0005524 IDA
    ATP-activated inward rectifier potassium channel activity GO:0015272 ISO
    protein binding GO:0005515 IPI
    ion channel binding GO:0044325 ISO
    inward rectifier potassium channel activity GO:0005242 IEA
    potassium ion binding GO:0030955 IC
Biological Process
    neurological system process GO:0050877 ISO
    regulation of membrane potential GO:0042391 ISO
    ion transport GO:0006811 IEA
    potassium ion transmembrane transport GO:0071805 ISO
    response to ATP GO:0033198 ISO
    transport GO:0006810 IEA
    potassium ion transport GO:0006813 ISO
    regulation of insulin secretion GO:0050796 ISO
    response to drug GO:0042493 ISO
    regulation of ion transmembrane transport GO:0034765 IDA
    positive regulation of cation channel activity GO:2001259 ISO
    potassium ion import GO:0010107 IDA
    glucose metabolic process GO:0006006 ISO
    negative regulation of insulin secretion GO:0046676 ISO
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    endoplasmic reticulum GO:0005783 ISO
    nuclear envelope GO:0005635 ISO
    neuronal cell body GO:0043025 ISO
    voltage-gated potassium channel complex GO:0008076 ISO
    ATP-sensitive potassium channel complex GO:0008282 ISO
    sarcolemma GO:0042383 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    cell body fiber GO:0070852 ISO
    endosome GO:0005768 ISO
    intercalated disc GO:0014704 ISO
    axolemma GO:0030673 ISO
    T-tubule GO:0030315 ISO
    integral component of plasma membrane GO:0005887 IBA
    cytosol GO:0005829 ISO
    mitochondrion GO:0005739 ISO
    myelin sheath GO:0043209 ISO
    membrane GO:0016020 IEA
    plasma membrane GO:0005886 ISO
 Experiment description of studies that identified Kcnj11 in exosomes
Experiment ID 15
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
 Protein-protein interactions for Kcnj11
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Kcnj11 is involved
ATP sensitive Potassium channels IEA Reactome
Regulation of insulin secretion IEA Reactome

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