Gene description for Kcnj3
Gene name potassium inwardly-rectifying channel, subfamily J, member 3
Gene symbol Kcnj3
Other names/aliases GIRK-1
GIRK1
Kcnf3
Kir3.1
Species Mus musculus
 Database cross references - Kcnj3
ExoCarta ExoCarta_16519
Vesiclepedia VP_16519
Entrez Gene 16519
UniProt P63250  
 Kcnj3 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Kcnj3
Molecular Function
    inward rectifier potassium channel activity GO:0005242 IBA
    inward rectifier potassium channel activity GO:0005242 ISO
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 ISS
    G-protein activated inward rectifier potassium channel activity GO:0015467 IDA
    G-protein activated inward rectifier potassium channel activity GO:0015467 TAS
    voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential GO:0099508 IEA
    voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential GO:0099508 ISO
Biological Process
    regulation of monoatomic ion transmembrane transport GO:0034765 IBA
    response to electrical stimulus GO:0051602 IEA
    potassium ion transmembrane transport GO:0071805 NAS
    regulation of presynaptic membrane potential GO:0099505 IEA
    potassium ion import across plasma membrane GO:1990573 IBA
    potassium ion import across plasma membrane GO:1990573 IEA
    potassium ion import across plasma membrane GO:1990573 ISO
Subcellular Localization
    plasma membrane GO:0005886 IBA
    voltage-gated potassium channel complex GO:0008076 ISO
    external side of plasma membrane GO:0009897 IEA
    external side of plasma membrane GO:0009897 ISO
    cell surface GO:0009986 ISO
    T-tubule GO:0030315 IEA
    T-tubule GO:0030315 ISO
    presynaptic membrane GO:0042734 IDA
    parallel fiber to Purkinje cell synapse GO:0098688 IDA
    I(KACh) inward rectifier potassium channel complex GO:1990566 ISO
 Experiment description of studies that identified Kcnj3 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Kcnj3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Sstr3  
Proximity Label-MS Mus musculus
View the network image/svg+xml



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