Gene description for Klf3
Gene name Kruppel-like factor 3 (basic)
Gene symbol Klf3
Other names/aliases 9930027G08Rik
AL024007
Bklf
Tef-2
Species Mus musculus
 Database cross references - Klf3
ExoCarta ExoCarta_16599
Vesiclepedia VP_16599
Entrez Gene 16599
UniProt Q60980  
 Klf3 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Klf3
Molecular Function
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IC
    DNA binding GO:0003677 ISS
    metal ion binding GO:0046872 IEA
    sequence-specific double-stranded DNA binding GO:1990837 ISO
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IMP
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    cellular response to peptide GO:1901653 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
 Experiment description of studies that identified Klf3 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Klf3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ctbp2  
Two-hybrid Mus musculus
Reconstituted Complex Mus musculus
2 Sqstm1  
Affinity Capture-Western Mus musculus
View the network image/svg+xml
 Pathways in which Klf3 is involved
No pathways found





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